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rdf:type |
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lifeskim:mentions |
|
|
pubmed:issue |
6
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pubmed:dateCreated |
1994-7-21
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|
pubmed:abstractText |
The transcriptional activator interferon regulatory factor 1 (IRF-1) and its antagonistic repressor IRF-2 are regulators of the interferon (IFN) system and of cell growth. Here we report that embryonic fibroblasts (EFs) from mice with a null mutation in the IRF-1 gene (IRF-1-/- mice) can be transformed by expression of an activated c-Ha-ras oncogene. This property is not observed in EFs from wild-type or IRF-2-/- mice but is still observed in EFs from mice deficient in both genes. The transformed phenotype of ras-expressing IRF-1-/- EFs could be suppressed by the expression of the IRF-1 cDNA. Thus, IRF-1 functions as a tumor suppressor. Furthermore, expression of the c-Ha-ras oncogene causes wild-type but not IRF-1-/- EFs to undergo apoptosis when combined with a block to cell proliferation or treated by anticancer drugs or ionizing radiation. Hence, IRF-1 may be a critical determinant of oncogene-induced cell transformation or apoptosis.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0092-8674
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
77
|
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pubmed:geneSymbol |
IRF-1,
ras
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
829-39
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8004672-Animals,
pubmed-meshheading:8004672-Antineoplastic Agents,
pubmed-meshheading:8004672-Apoptosis,
pubmed-meshheading:8004672-Base Sequence,
pubmed-meshheading:8004672-Cell Line,
pubmed-meshheading:8004672-Cell Survival,
pubmed-meshheading:8004672-Cell Transformation, Neoplastic,
pubmed-meshheading:8004672-DNA,
pubmed-meshheading:8004672-DNA-Binding Proteins,
pubmed-meshheading:8004672-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:8004672-Genes, ras,
pubmed-meshheading:8004672-Interferon Regulatory Factor-1,
pubmed-meshheading:8004672-Mice,
pubmed-meshheading:8004672-Mice, Inbred BALB C,
pubmed-meshheading:8004672-Mice, Knockout,
pubmed-meshheading:8004672-Molecular Sequence Data,
pubmed-meshheading:8004672-Mutation,
pubmed-meshheading:8004672-Neoplasms, Experimental,
pubmed-meshheading:8004672-Phosphoproteins,
pubmed-meshheading:8004672-Transcription Factors
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pubmed:year |
1994
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pubmed:articleTitle |
Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1.
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pubmed:affiliation |
Institute for Molecular and Cellular Biology, Osaka University, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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