| pubmed-article:8001557 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8001557 | lifeskim:mentions | umls-concept:C0085828 | lld:lifeskim |
| pubmed-article:8001557 | lifeskim:mentions | umls-concept:C0026844 | lld:lifeskim |
| pubmed-article:8001557 | lifeskim:mentions | umls-concept:C1135918 | lld:lifeskim |
| pubmed-article:8001557 | lifeskim:mentions | umls-concept:C0020281 | lld:lifeskim |
| pubmed-article:8001557 | lifeskim:mentions | umls-concept:C0033634 | lld:lifeskim |
| pubmed-article:8001557 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:8001557 | lifeskim:mentions | umls-concept:C0969677 | lld:lifeskim |
| pubmed-article:8001557 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:8001557 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8001557 | pubmed:dateCreated | 1995-1-26 | lld:pubmed |
| pubmed-article:8001557 | pubmed:abstractText | The effects of hydrogen peroxide D-alpha-tocopherol and of D-beta-tocopherol on proliferation, protein kinase C and activator protein-1 (AP-1) activation have been studied in vascular smooth muscle cells. Cell proliferation, when activated by foetal calf serum, was inhibited by D-alpha-tocopherol. Protein kinase C activity was stimulated by hydrogen peroxide in a manner similar to phorbol myristate acetate; in the latter case, but not in the former, D-alpha-tocopherol inhibited the reaction. Hydrogen peroxide prevented phorbol-myristate-acetate-stimulated AP-1 binding to DNA but stimulated it if protein kinase C was down-regulated or inhibited. D-alpha-Tocopherol promoted AP-1 activation in quiescent cells but prevented its activation by phorbol myristate acetate. None of the described effects of D-alpha-tocopherol were shared by D-beta-tocopherol, suggesting a non-antioxidant mechanism as the basis of its action. The data show that hydrogen peroxide and D-alpha-tocopherol affect more than one element in the cell signal-transduction cascade. | lld:pubmed |
| pubmed-article:8001557 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8001557 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8001557 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8001557 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8001557 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8001557 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8001557 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8001557 | pubmed:issn | 0014-2956 | lld:pubmed |
| pubmed-article:8001557 | pubmed:author | pubmed-author:AzziAA | lld:pubmed |
| pubmed-article:8001557 | pubmed:author | pubmed-author:BoscoboinikDD | lld:pubmed |
| pubmed-article:8001557 | pubmed:author | pubmed-author:StäubleBB | lld:pubmed |
| pubmed-article:8001557 | pubmed:author | pubmed-author:TasinatoAA | lld:pubmed |
| pubmed-article:8001557 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8001557 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8001557 | pubmed:volume | 226 | lld:pubmed |
| pubmed-article:8001557 | pubmed:geneSymbol | c-fos | lld:pubmed |
| pubmed-article:8001557 | pubmed:geneSymbol | c-jun | lld:pubmed |
| pubmed-article:8001557 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8001557 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8001557 | pubmed:pagination | 393-402 | lld:pubmed |
| pubmed-article:8001557 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:8001557 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8001557 | pubmed:articleTitle | Modulation of activator protein-1 (AP-1) transcription factor and protein kinase C by hydrogen peroxide and D-alpha-tocopherol in vascular smooth muscle cells. | lld:pubmed |
| pubmed-article:8001557 | pubmed:affiliation | Institut für Biochemie und Molekularbiologie, Universität Bern, Switzerland. | lld:pubmed |
| pubmed-article:8001557 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8001557 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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