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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1995-1-26
|
| pubmed:abstractText |
The effects of hydrogen peroxide D-alpha-tocopherol and of D-beta-tocopherol on proliferation, protein kinase C and activator protein-1 (AP-1) activation have been studied in vascular smooth muscle cells. Cell proliferation, when activated by foetal calf serum, was inhibited by D-alpha-tocopherol. Protein kinase C activity was stimulated by hydrogen peroxide in a manner similar to phorbol myristate acetate; in the latter case, but not in the former, D-alpha-tocopherol inhibited the reaction. Hydrogen peroxide prevented phorbol-myristate-acetate-stimulated AP-1 binding to DNA but stimulated it if protein kinase C was down-regulated or inhibited. D-alpha-Tocopherol promoted AP-1 activation in quiescent cells but prevented its activation by phorbol myristate acetate. None of the described effects of D-alpha-tocopherol were shared by D-beta-tocopherol, suggesting a non-antioxidant mechanism as the basis of its action. The data show that hydrogen peroxide and D-alpha-tocopherol affect more than one element in the cell signal-transduction cascade.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrogen Peroxide,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor AP-1,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin E
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0014-2956
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
226
|
| pubmed:geneSymbol |
c-fos,
c-jun
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
393-402
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8001557-Animals,
pubmed-meshheading:8001557-Aorta,
pubmed-meshheading:8001557-Base Sequence,
pubmed-meshheading:8001557-Blotting, Northern,
pubmed-meshheading:8001557-Cell Division,
pubmed-meshheading:8001557-Cell Line,
pubmed-meshheading:8001557-Cells, Cultured,
pubmed-meshheading:8001557-DNA,
pubmed-meshheading:8001557-Gene Expression,
pubmed-meshheading:8001557-Genes, fos,
pubmed-meshheading:8001557-Genes, jun,
pubmed-meshheading:8001557-Hydrogen Peroxide,
pubmed-meshheading:8001557-Molecular Sequence Data,
pubmed-meshheading:8001557-Muscle, Smooth, Vascular,
pubmed-meshheading:8001557-Protein Kinase C,
pubmed-meshheading:8001557-Rats,
pubmed-meshheading:8001557-Tetradecanoylphorbol Acetate,
pubmed-meshheading:8001557-Transcription Factor AP-1,
pubmed-meshheading:8001557-Vitamin E
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Modulation of activator protein-1 (AP-1) transcription factor and protein kinase C by hydrogen peroxide and D-alpha-tocopherol in vascular smooth muscle cells.
|
| pubmed:affiliation |
Institut für Biochemie und Molekularbiologie, Universität Bern, Switzerland.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|