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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1995-1-24
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pubmed:abstractText |
Studies of T cell responses to altered peptide ligands (APLs) have provided functional evidence that a T cell receptor (TCR) can interpret subtle changes in its ligand, resulting in different phenotypic outcomes. One dramatic effect of APL stimulation with live antigen-presenting cells (APCs) is the induction of energy as opposed to proliferation. We investigated the intracellular signaling events involved in generating this unresponsiveness by comparing protein-tyrosine phosphorylation patterns after stimulation with anergy-inducing APL or the immunogenic peptide. In resting T cell clones, presentation with APL/live APC stimulated a unique pattern of TCR phospho-zeta species and a subsequent lack of association with zap70. This demonstrates that the TCR-CD3 complex can engage selective intracellular biochemical signaling pathways as a direct consequence of the nature of the ligand recognized and the initial phosphotyrosine pattern of the TCR-CD3 proteins, leading to different phenotypes.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobins,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/ZAP-70 Protein-Tyrosine Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/Zap70 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/antigen T cell receptor, zeta chain,
http://linkedlifedata.com/resource/pubmed/chemical/hemoglobin (64-76)
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
913-22
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8001128-Amino Acid Sequence,
pubmed-meshheading:8001128-Animals,
pubmed-meshheading:8001128-Antigen Presentation,
pubmed-meshheading:8001128-Clonal Anergy,
pubmed-meshheading:8001128-Hemoglobins,
pubmed-meshheading:8001128-Ligands,
pubmed-meshheading:8001128-Membrane Proteins,
pubmed-meshheading:8001128-Mice,
pubmed-meshheading:8001128-Mice, Inbred Strains,
pubmed-meshheading:8001128-Models, Immunological,
pubmed-meshheading:8001128-Molecular Sequence Data,
pubmed-meshheading:8001128-Peptide Fragments,
pubmed-meshheading:8001128-Phosphorylation,
pubmed-meshheading:8001128-Protein-Tyrosine Kinases,
pubmed-meshheading:8001128-Receptors, Antigen, T-Cell,
pubmed-meshheading:8001128-Signal Transduction,
pubmed-meshheading:8001128-T-Lymphocytes,
pubmed-meshheading:8001128-ZAP-70 Protein-Tyrosine Kinase
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pubmed:year |
1994
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pubmed:articleTitle |
Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy.
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pubmed:affiliation |
Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.
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pubmed:publicationType |
Journal Article
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