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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6506
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pubmed:dateCreated |
1995-1-10
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pubmed:databankReference |
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pubmed:abstractText |
Cells of the yeast Saccharomyces cerevisiae choose bud sites in a non-random spatial pattern that depends on mating type: axial for haploid cells and bipolar for a/alpha diploid cells. We identified a mutant yeast, axl 1, in which the budding pattern is altered from axial to bipolar. Expression of the AXL1 gene is repressed in a/alpha diploid cells. With the ectopic expression of AXL1, a/alpha cells exhibited an axial budding pattern, thus AXL1 is a key morphological determinant that distinguishes the budding pattern of haploid cells from that of a/alpha diploid cells. AXL1 encodes a protein similar in sequence of the human and Drosophila insulin-degrading enzymes and to the Escherichia coli ptr gene product. The axial budding pattern might result from degradation of a target protein by the putative Axl1 protease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
372
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pubmed:geneSymbol |
AXL1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
567-70
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:7990931-Amino Acid Sequence,
pubmed-meshheading:7990931-Animals,
pubmed-meshheading:7990931-Base Sequence,
pubmed-meshheading:7990931-Cell Division,
pubmed-meshheading:7990931-DNA,
pubmed-meshheading:7990931-Drosophila,
pubmed-meshheading:7990931-Fungal Proteins,
pubmed-meshheading:7990931-Genes, Fungal,
pubmed-meshheading:7990931-Genes, Mating Type, Fungal,
pubmed-meshheading:7990931-Humans,
pubmed-meshheading:7990931-Insulin,
pubmed-meshheading:7990931-Metalloendopeptidases,
pubmed-meshheading:7990931-Molecular Sequence Data,
pubmed-meshheading:7990931-Mutation,
pubmed-meshheading:7990931-Restriction Mapping,
pubmed-meshheading:7990931-Saccharomyces cerevisiae,
pubmed-meshheading:7990931-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:7990931-Sequence Homology, Amino Acid
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pubmed:year |
1994
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pubmed:articleTitle |
A yeast gene necessary for bud-site selection encodes a protein similar to insulin-degrading enzymes.
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pubmed:affiliation |
National Institute of Bioscience and Human-Technology, Tsukuba, Japan.
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pubmed:publicationType |
Journal Article
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