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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
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pubmed:dateCreated |
1995-1-12
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pubmed:abstractText |
In white populations, a deletion polymorphism in the gene for angiotensin converting enzyme (ACE) appears to be associated with increased risk for myocardial infarction but not for hypertension. In a population-association study in African-Americans, we compared the frequency of the ACE deletion polymorphism in subjects with hypertension versus those with normal blood pressure. The frequency of the ACE deletion allele was greater in African-Americans with hypertension than in those with normal blood pressure (P < 0.05). These findings raise the possibility that in some patient subgroups, sequence variation in or near the ACE gene may contribute to the risk for hypertension.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
|
pubmed:issn |
0895-7061
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
759-62
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pubmed:dateRevised |
2009-2-24
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pubmed:meshHeading |
pubmed-meshheading:7986468-Adult,
pubmed-meshheading:7986468-African Continental Ancestry Group,
pubmed-meshheading:7986468-Alleles,
pubmed-meshheading:7986468-Base Sequence,
pubmed-meshheading:7986468-Gene Deletion,
pubmed-meshheading:7986468-Genotype,
pubmed-meshheading:7986468-Humans,
pubmed-meshheading:7986468-Hypertension,
pubmed-meshheading:7986468-Middle Aged,
pubmed-meshheading:7986468-Molecular Sequence Data,
pubmed-meshheading:7986468-Peptidyl-Dipeptidase A,
pubmed-meshheading:7986468-Polymerase Chain Reaction,
pubmed-meshheading:7986468-Polymorphism, Genetic
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pubmed:year |
1994
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pubmed:articleTitle |
Frequency of a deletion polymorphism in the gene for angiotensin converting enzyme is increased in African-Americans with hypertension.
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pubmed:affiliation |
Department of Medicine, Wayne State University, Detroit, Michigan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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