| pubmed-article:7983749 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7983749 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:7983749 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:7983749 | lifeskim:mentions | umls-concept:C0019691 | lld:lifeskim |
| pubmed-article:7983749 | lifeskim:mentions | umls-concept:C0333117 | lld:lifeskim |
| pubmed-article:7983749 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:7983749 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:7983749 | lifeskim:mentions | umls-concept:C1446680 | lld:lifeskim |
| pubmed-article:7983749 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:7983749 | lifeskim:mentions | umls-concept:C0205163 | lld:lifeskim |
| pubmed-article:7983749 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:7983749 | lifeskim:mentions | umls-concept:C0210233 | lld:lifeskim |
| pubmed-article:7983749 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7983749 | pubmed:dateCreated | 1995-1-5 | lld:pubmed |
| pubmed-article:7983749 | pubmed:abstractText | Human immunodeficiency virus type 1 (HIV-1) variants passaged in T-cell lines, often called laboratory isolates, are potently neutralized by soluble CD4 (sCD4), whereas primary HIV-1 variants are highly resistant to sCD4 neutralization. Previously, it was demonstrated that the domain from V1 to V3 of the HIV-1 gp120 molecule contains one of the major determinants of sCD4 neutralization sensitivity, and the same region has also been implicated as influencing syncytium-inducing (SI) capacity and T-cell-line tropism. To determine possible differences in sCD4 neutralization sensitivity between phenotypically distinct primary HIV-1 variants, a panel of non-syncytium-inducing (NSI) and SI HIV-1 variants was studied. Primary NSI and SI HIV-1 variants appeared to be equally resistant to sCD4 neutralization. Consistent with this observation, sCD4 did not induce gp120 shedding from either primary NSI or SI HIV-1 variants at 37 degrees C. Thus, it is not the potential of certain primary HIV-1 variants to infect T-cell lines but rather their adaptation to T-cell lines that is reflected in specific properties of the viral envelope which influence sCD4 neutralization sensitivity. | lld:pubmed |
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| pubmed-article:7983749 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7983749 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7983749 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7983749 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7983749 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7983749 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:7983749 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:7983749 | pubmed:author | pubmed-author:MooreJ PJP | lld:pubmed |
| pubmed-article:7983749 | pubmed:author | pubmed-author:SchuitemakerH... | lld:pubmed |
| pubmed-article:7983749 | pubmed:author | pubmed-author:GroeninkMM | lld:pubmed |
| pubmed-article:7983749 | pubmed:author | pubmed-author:BroersenSS | lld:pubmed |
| pubmed-article:7983749 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7983749 | pubmed:volume | 69 | lld:pubmed |
| pubmed-article:7983749 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7983749 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7983749 | pubmed:pagination | 523-7 | lld:pubmed |
| pubmed-article:7983749 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:7983749 | pubmed:meshHeading | pubmed-meshheading:7983749-... | lld:pubmed |
| pubmed-article:7983749 | pubmed:meshHeading | pubmed-meshheading:7983749-... | lld:pubmed |
| pubmed-article:7983749 | pubmed:meshHeading | pubmed-meshheading:7983749-... | lld:pubmed |
| pubmed-article:7983749 | pubmed:meshHeading | pubmed-meshheading:7983749-... | lld:pubmed |
| pubmed-article:7983749 | pubmed:meshHeading | pubmed-meshheading:7983749-... | lld:pubmed |
| pubmed-article:7983749 | pubmed:meshHeading | pubmed-meshheading:7983749-... | lld:pubmed |
| pubmed-article:7983749 | pubmed:meshHeading | pubmed-meshheading:7983749-... | lld:pubmed |
| pubmed-article:7983749 | pubmed:meshHeading | pubmed-meshheading:7983749-... | lld:pubmed |
| pubmed-article:7983749 | pubmed:meshHeading | pubmed-meshheading:7983749-... | lld:pubmed |
| pubmed-article:7983749 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7983749 | pubmed:articleTitle | Equal levels of gp120 retention and neutralization resistance of phenotypically distinct primary human immunodeficiency virus type 1 variants upon soluble CD4 treatment. | lld:pubmed |
| pubmed-article:7983749 | pubmed:affiliation | Department of Clinical Viro-Immunology, The Netherlands Red Cross Blood Transfusion Service, Amsterdam. | lld:pubmed |
| pubmed-article:7983749 | pubmed:publicationType | Journal Article | lld:pubmed |
