|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0013081,
umls-concept:C0017262,
umls-concept:C0017638,
umls-concept:C0020200,
umls-concept:C0027819,
umls-concept:C0086376,
umls-concept:C0330390,
umls-concept:C0439792,
umls-concept:C0470187,
umls-concept:C0597357,
umls-concept:C1171362,
umls-concept:C1515670
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|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1995-1-3
|
|
pubmed:abstractText |
Sustained exposure of neuroblastoma x glioma hybrid, NG108-15, cells transfected to express the human beta 2-adrenoceptor (clone beta N22) to isoprenaline or iloprost (an agonist at the endogenously expressed IP prostanoid receptor) resulted in a substantial and selective down-regulation of the alpha subunit of the G-protein Gs. Treatment of these cells with the irreversible beta-adrenoceptor antagonist bromoacetyl alprenolol menthane diminished both the potency and the maximal ability of isoprenaline but not of iloprost to cause Gs alpha down-regulation. These results demonstrate that the extent of agonist-mediated Gs alpha down-regulation is dependent upon the availability of receptor to agonist.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0014-5793
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|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
28
|
|
pubmed:volume |
355
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
166-70
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|
pubmed:dateRevised |
2010-11-18
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|
pubmed:meshHeading |
pubmed-meshheading:7982493-Adenylate Cyclase,
pubmed-meshheading:7982493-Adrenergic beta-2 Receptor Antagonists,
pubmed-meshheading:7982493-Alprenolol,
pubmed-meshheading:7982493-Down-Regulation,
pubmed-meshheading:7982493-GTP-Binding Proteins,
pubmed-meshheading:7982493-Gene Expression,
pubmed-meshheading:7982493-Glioma,
pubmed-meshheading:7982493-Humans,
pubmed-meshheading:7982493-Hybrid Cells,
pubmed-meshheading:7982493-Isoproterenol,
pubmed-meshheading:7982493-Neuroblastoma,
pubmed-meshheading:7982493-Receptors, Adrenergic, beta-2,
pubmed-meshheading:7982493-Tumor Cells, Cultured
|
|
pubmed:year |
1994
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|
pubmed:articleTitle |
Receptor availability defines the extent of agonist-mediated G-protein down-regulation in neuroblastoma x glioma hybrid cells transfected to express the beta 2-adrenoceptor.
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|
pubmed:affiliation |
Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Scotland, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
