Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1994-12-20
|
pubmed:abstractText |
With enzyme immunoassay, maternal serum chorionic gonadotropin (MShCG) level was determined in 58 pregnancies affected with fetal homozygous alpha-thalassemia 1. In 40 pregnancies with a gestational age of 10 to 14 weeks, 8 (20%) had an MShCG level above 2.5 multiples of the median (MoM); while in the other 18 pregnancies with a gestational age of 15 to 23 weeks, 14 (78%) had a level above 2.5 MoMs and none had a level below the median. Homozygous alpha-thalassemia 1 of the fetus was associated with an elevated MShCG. Therefore in second-trimester screening for Down's syndrome by measurement of MShCG, homozygous alpha-thalassemia 1 should also be considered if elevated MShCG levels are found.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0932-0067
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
255
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
113-7
|
pubmed:dateRevised |
2009-11-19
|
pubmed:meshHeading |
pubmed-meshheading:7979563-Adult,
pubmed-meshheading:7979563-Chorionic Gonadotropin,
pubmed-meshheading:7979563-Female,
pubmed-meshheading:7979563-Genetic Testing,
pubmed-meshheading:7979563-Homozygote,
pubmed-meshheading:7979563-Humans,
pubmed-meshheading:7979563-Infant, Newborn,
pubmed-meshheading:7979563-Pregnancy,
pubmed-meshheading:7979563-Pregnancy Trimester, Second,
pubmed-meshheading:7979563-Prenatal Diagnosis,
pubmed-meshheading:7979563-Risk Factors,
pubmed-meshheading:7979563-alpha-Thalassemia
|
pubmed:year |
1994
|
pubmed:articleTitle |
Increased level of second trimester maternal serum chorionic gonadotropin in pregnancy with a fetus affected by homozygous alpha-thalassemia 1.
|
pubmed:affiliation |
Department of Medical Genetics, College of Medicine, National Taiwan University, Taipei, Republic of China.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|