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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1994-12-23
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pubmed:abstractText |
Hypercholesterolaemia is a major risk factor for the development of coronary heart disease (CHD). Early detection and management of hypercholesterolaemia could retard the atherosclerotic process. Given that CHD and hypercholesterolaemia cluster within families, a screening strategy based on a family history of vascular disease has been advocated. Serum total cholesterol concentrations were measured in a random stratified sample of 1012 children aged from 12-15 years old participating in a coronary risk factor surveillance study in Northern Ireland. Information about vascular disease in close family members was obtained by means of a questionnaire. The study population was divided into two groups according to total cholesterol values: (i) normal, < 5.2 mmol/l (n = 822) and (ii) raised, > or = 5.2 mmol/l (n = 190). A family history identified 63 out of 190 individuals with hypercholesterolaemia yielding a sensitivity of 33.2% and specificity of 71.5%. Our data indicated that a strategy whereby only children from high risk families are screened for hypercholesterolaemia is ineffective. While primary prevention emphasising a healthy diet for all is essential, the role of universal screening deserves further appraisal.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7979498-1342780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7979498-1617335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7979498-1805810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7979498-1861925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7979498-1927531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7979498-2028978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7979498-2563518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7979498-2640549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7979498-2662178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7979498-2718985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7979498-2754548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7979498-2801654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7979498-3455748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7979498-3737258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7979498-3737309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7979498-3773199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7979498-3986055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7979498-5346899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7979498-6331147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7979498-6578354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7979498-6620483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7979498-6847791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7979498-8361788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7979498-8481039
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1468-2044
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
239-42
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7979498-Adolescent,
pubmed-meshheading:7979498-Age Factors,
pubmed-meshheading:7979498-Child,
pubmed-meshheading:7979498-Cholesterol,
pubmed-meshheading:7979498-Female,
pubmed-meshheading:7979498-Humans,
pubmed-meshheading:7979498-Hypercholesterolemia,
pubmed-meshheading:7979498-Male,
pubmed-meshheading:7979498-Mass Screening,
pubmed-meshheading:7979498-Random Allocation,
pubmed-meshheading:7979498-Risk Factors,
pubmed-meshheading:7979498-Sensitivity and Specificity,
pubmed-meshheading:7979498-Sex Factors,
pubmed-meshheading:7979498-Vascular Diseases
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pubmed:year |
1994
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pubmed:articleTitle |
Cholesterol screening and family history of vascular disease.
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pubmed:affiliation |
Department of Child Health, Institute of Clinical Science, Royal Victoria Hospital, Belfast.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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