Linked Life Data

7976355

Source:http://linkedlifedata.com/resource/pubmed/id/7976355

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1994-12-13
pubmed:abstractText
A new animal model of hyperglycemia and hyperlipidemia was established by treating normal Kunming mice with alloxan (iv). After different time intervals, the levels of blood glucose (BG) and serum triglyceride (TG) were determined. Forty-eight h after alloxan administration, the BG increased significantly, and the level of serum triglyceride reached maximum. The levels of blood glucose, serum triglyceride, cholesterol (CHOL) and free fatty acid (FFA) for vehicle treated mice were about 3.1, 4.0, 1.1, and 1.7 times those of normal Kunming mice, respectively. To evaluate the new animal model, four drugs were used. Two of them were antihyperglycemic drugs, metformin and a Recipe of Chinese Herbs (RCH). The other two were antihyperlipidemic agents, clofibrate and fenofibrate. All drugs showed positive effects on this kind of alloxan-diabetic Kunming mice. It can be concluded that this kind of alloxan-treated Kunming mice is useful for testing hypoglycemic and hypolipidemic drugs.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0513-4870
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
387-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
[An animal model for testing hypoglycemic and hypolipidemic drugs].
pubmed:affiliation
Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing.
pubmed:publicationType
Journal Article, English Abstract