Linked Life Data

7976005

Source:http://linkedlifedata.com/resource/pubmed/id/7976005

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-11-28
pubmed:abstractText
Previous experiments have shown that the reorganization of the hand representations in areas 3b and 1 of somatosensory cortex of monkeys can be extensive or limited, depending on the pattern of peripheral sensory loss. After the loss of two or more digits, the deprived zones of cortex are not fully reactivated by remaining inputs from the hand (Merzenich et al., 1984). In contrast, after deafferentation of the entire glabrous surface of the hand, the deprived cortex becomes responsive throughout its extent to cutaneous stimulation of the dorsal hairy surface of the hand (Garraghty and Kaas, 1991). To test the hypothesis that it is the pattern of sensory loss and not the deprivation procedure that results in these differences, we mimicked multiple-digit amputation by deafferenting corresponding parts of the dorsal and ventral hand. We then recorded from areas 3b and 1 of 3 squirrel monkeys 3-11 months after the deafferentation. In each case, much of the cortex normally activated by the removed inputs remained unresponsive to cutaneous stimulation of skin surfaces of the hand with intact innervation. Thus, the reorganization that can occur in somatosensory cortex following peripheral sensory loss is constrained by the precise content of the stimulus deprivation; that is, there is a limit to the set of new receptive fields cortical neurons can acquire.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0899-0220
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
109-17
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Pattern of peripheral deafferentation predicts reorganizational limits in adult primate somatosensory cortex.
pubmed:affiliation
Department of Psychology, Indiana University, Bloomington 47405.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't