Linked Life Data

7971181

Source:http://linkedlifedata.com/resource/pubmed/id/7971181

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1994-12-28
pubmed:abstractText
The purpose of this study was to quantify the uptake and excretion of Tc-99m-N-pyridoxyl-5-methyltryptophan (PMT) by hepatocytes using a tracer kinetic modeling approach, and to clarify the pathophysiological changes of diffuse parenchymal liver diseases. Fifty-two patients with liver diseases and seven normal subjects were studied. Studies were performed using an intravenous bolus injection of 185 MBq of PMT. Our compartment model consisted of three compartments. These parameters were calculated using the non-linear least-square method. The fitting curves agreed well with the measured ones. K1 correlated with blood tests of liver function better than parameters from the two-compartment model such as ku. K1 correlated especially closely with K-ICG (r = 0.898). K1 reflected hepatic blood flow, and the decrease of K1 was associated with hepatic dysfunction. Although K3 correlated poorly with serum bilirubin (r = -0.447), it correlated well with MTT (deconvolutional analysis) (r = -0.833). K3 reflected excretory function, and did not decrease until liver function was moderately damaged. By using three-compartment analysis, we were better able to explain the pathophysiological status of the liver. Our model is more useful for the assessment of liver function than the simple model.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0048-0428
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1030-40
pubmed:dateRevised
2011-7-26
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
[Clinical evaluation of kinetic model for the quantification of liver function with Tc-99m PMT and dynamic scintigraphy].
pubmed:affiliation
Department of Radiology, Ehime University School of Medicine.
pubmed:publicationType
Journal Article, English Abstract