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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1994-11-29
|
| pubmed:abstractText |
Crescentic glomerulonephritis is usually classified into antiglomerular basement membrane (GBM) disease, immune-complex disease, or pauci-immune crescentic nephritis. The last category includes patients with systemic vasculitis as well as 'idiopathic' isolated crescentic nephritis. The presence of anti-neutrophil cytoplasmic antibodies (ANCA) in many patients with apparently isolated crescentic nephritis suggests that this represents a renal-limited form of vasculitis, and that truly 'idiopathic' crescentic nephritis is a very rare entity. We reviewed all renal biopsies with extracapillary proliferation seen at our centre since the availability of an ANCA assay (4-year period). There were 89 such biopsies of a total of 1240, of which 82 had sufficient details for further analysis. Of these, 10 had anti-GBM disease, 35 had epithelial proliferation associated with a variety of other diseases, and 36 had ANCA-associated disease. Nine of this last group had no extrarenal features and would previously have been classified as 'idiopathic' crescentic glomerulonephritis. The single remaining patient had an inactive glomerulonephritis with a scarred crescent; the predominant lesion was an interstitial nephritis. We therefore conclude that truly 'idiopathic' crescentic nephritis is very rare, if it exists at all. The ability to provide a practically complete classification of crescentic nephritis has important prognostic and therapeutic consequences.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0931-0509
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
630-6
|
| pubmed:dateRevised |
2010-8-25
|
| pubmed:meshHeading |
pubmed-meshheading:7970088-Adolescent,
pubmed-meshheading:7970088-Adult,
pubmed-meshheading:7970088-Aged,
pubmed-meshheading:7970088-Aged, 80 and over,
pubmed-meshheading:7970088-Antibodies, Antineutrophil Cytoplasmic,
pubmed-meshheading:7970088-Autoantibodies,
pubmed-meshheading:7970088-Biological Markers,
pubmed-meshheading:7970088-Biopsy,
pubmed-meshheading:7970088-Diagnosis, Differential,
pubmed-meshheading:7970088-Female,
pubmed-meshheading:7970088-Glomerulonephritis,
pubmed-meshheading:7970088-Humans,
pubmed-meshheading:7970088-Immune Complex Diseases,
pubmed-meshheading:7970088-Kidney Glomerulus,
pubmed-meshheading:7970088-Male,
pubmed-meshheading:7970088-Middle Aged,
pubmed-meshheading:7970088-Neutrophils,
pubmed-meshheading:7970088-Vasculitis
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Does truly 'idiopathic' crescentic glomerulonephritis exist?
|
| pubmed:affiliation |
Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, UK.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|