| pubmed-article:7969471 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7969471 | lifeskim:mentions | umls-concept:C0015576 | lld:lifeskim |
| pubmed-article:7969471 | lifeskim:mentions | umls-concept:C0680022 | lld:lifeskim |
| pubmed-article:7969471 | lifeskim:mentions | umls-concept:C0027754 | lld:lifeskim |
| pubmed-article:7969471 | lifeskim:mentions | umls-concept:C0027752 | lld:lifeskim |
| pubmed-article:7969471 | lifeskim:mentions | umls-concept:C0170842 | lld:lifeskim |
| pubmed-article:7969471 | pubmed:issue | 6503 | lld:pubmed |
| pubmed-article:7969471 | pubmed:dateCreated | 1994-12-9 | lld:pubmed |
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| pubmed-article:7969471 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969471 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969471 | pubmed:abstractText | During vertebrate development, many neurons depend for survival and differentiation on their target cells. The best documented mediator of such a retrograde trophic action is the neurotrophin nerve growth factor (NGF). NGF and the other known members of the neurotrophin family, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5) are conserved as distinct genes over large evolutionary distances. Here we report the cloning of neurotrophin-6 (NT-6), a new member of this family from the teleost fish Xiphophorus. NT-6 distinguishes itself from the other known neurotrophins in that it is not found as a soluble protein in the medium of producing cells. The addition of heparin (but not chondroitin) effects the release of NT-6 from cell surface and extracellular matrix molecules. Recombinant purified NT-6 has a spectrum of actions similar to NGF on chick sympathetic and sensory neurons, albeit with a lower potency. NT-6 is expressed in the embryonic valvulla cerebelli; expression persists in some adult tissues. The interaction of NT-6 with heparin-binding molecules may modulate its action in the nervous system. | lld:pubmed |
| pubmed-article:7969471 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7969471 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969471 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7969471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7969471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7969471 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7969471 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7969471 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:7969471 | pubmed:author | pubmed-author:ThoenenHH | lld:pubmed |
| pubmed-article:7969471 | pubmed:author | pubmed-author:GöttHH | lld:pubmed |
| pubmed-article:7969471 | pubmed:author | pubmed-author:WinklerCC | lld:pubmed |
| pubmed-article:7969471 | pubmed:author | pubmed-author:KösterRR | lld:pubmed |
| pubmed-article:7969471 | pubmed:author | pubmed-author:SchartlMM | lld:pubmed |
| pubmed-article:7969471 | pubmed:author | pubmed-author:LottspeichFF | lld:pubmed |
| pubmed-article:7969471 | pubmed:author | pubmed-author:RaulfFF | lld:pubmed |
| pubmed-article:7969471 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7969471 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:7969471 | pubmed:volume | 372 | lld:pubmed |
| pubmed-article:7969471 | pubmed:geneSymbol | NT-6 | lld:pubmed |
| pubmed-article:7969471 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7969471 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7969471 | pubmed:pagination | 266-9 | lld:pubmed |
| pubmed-article:7969471 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:7969471 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7969471 | pubmed:articleTitle | Neurotrophin-6 is a new member of the nerve growth factor family. | lld:pubmed |
| pubmed-article:7969471 | pubmed:affiliation | Max-Planck-Institute for Psychiatry, Department of Neurochemistry, Martinsried, Germany. | lld:pubmed |
| pubmed-article:7969471 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7969471 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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