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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6503
|
| pubmed:dateCreated |
1994-12-9
|
| pubmed:databankReference | |
| pubmed:abstractText |
During vertebrate development, many neurons depend for survival and differentiation on their target cells. The best documented mediator of such a retrograde trophic action is the neurotrophin nerve growth factor (NGF). NGF and the other known members of the neurotrophin family, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5) are conserved as distinct genes over large evolutionary distances. Here we report the cloning of neurotrophin-6 (NT-6), a new member of this family from the teleost fish Xiphophorus. NT-6 distinguishes itself from the other known neurotrophins in that it is not found as a soluble protein in the medium of producing cells. The addition of heparin (but not chondroitin) effects the release of NT-6 from cell surface and extracellular matrix molecules. Recombinant purified NT-6 has a spectrum of actions similar to NGF on chick sympathetic and sensory neurons, albeit with a lower potency. NT-6 is expressed in the embryonic valvulla cerebelli; expression persists in some adult tissues. The interaction of NT-6 with heparin-binding molecules may modulate its action in the nervous system.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Heparin,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Proteoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/neurotrophin 6
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0028-0836
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
17
|
| pubmed:volume |
372
|
| pubmed:geneSymbol |
NT-6
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
266-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7969471-Amino Acid Sequence,
pubmed-meshheading:7969471-Animals,
pubmed-meshheading:7969471-Cell Division,
pubmed-meshheading:7969471-Cell Line,
pubmed-meshheading:7969471-Chick Embryo,
pubmed-meshheading:7969471-Cloning, Molecular,
pubmed-meshheading:7969471-Cyprinodontiformes,
pubmed-meshheading:7969471-Extracellular Matrix,
pubmed-meshheading:7969471-Heparin,
pubmed-meshheading:7969471-Humans,
pubmed-meshheading:7969471-Mice,
pubmed-meshheading:7969471-Molecular Sequence Data,
pubmed-meshheading:7969471-Nerve Growth Factors,
pubmed-meshheading:7969471-Neurons,
pubmed-meshheading:7969471-Protein Binding,
pubmed-meshheading:7969471-Proteoglycans,
pubmed-meshheading:7969471-Rabbits,
pubmed-meshheading:7969471-Recombinant Proteins,
pubmed-meshheading:7969471-Sequence Homology, Amino Acid,
pubmed-meshheading:7969471-Solubility
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Neurotrophin-6 is a new member of the nerve growth factor family.
|
| pubmed:affiliation |
Max-Planck-Institute for Psychiatry, Department of Neurochemistry, Martinsried, Germany.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|