| pubmed-article:7968380 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7968380 | lifeskim:mentions | umls-concept:C0009015 | lld:lifeskim |
| pubmed-article:7968380 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:7968380 | lifeskim:mentions | umls-concept:C0012940 | lld:lifeskim |
| pubmed-article:7968380 | lifeskim:mentions | umls-concept:C0033681 | lld:lifeskim |
| pubmed-article:7968380 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:7968380 | lifeskim:mentions | umls-concept:C1519249 | lld:lifeskim |
| pubmed-article:7968380 | lifeskim:mentions | umls-concept:C1710236 | lld:lifeskim |
| pubmed-article:7968380 | lifeskim:mentions | umls-concept:C0071827 | lld:lifeskim |
| pubmed-article:7968380 | pubmed:issue | 1-4 | lld:pubmed |
| pubmed-article:7968380 | pubmed:dateCreated | 1994-12-7 | lld:pubmed |
| pubmed-article:7968380 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7968380 | pubmed:abstractText | A 90 bp fragment prepared from the promoter region of the rat preprodynorphin gene formed a complex with rat brain nuclear extracts as assessed by gel mobility shift assays. An 8 base pair sequence, CACTCTCC, termed upstream regulatory element (URE), was identified within this fragment as a binding site by DNase 1 footprint analysis and gel mobility shift assays with synthetic oligonucleotides. The URE is a consensus sequence for a transcription initiator (Inr) element although in the preprodynorphin promoter it is located upstream at -208 and overlaps a region conserved between rat and human promoters. A unique 310 amino acid protein (UreB1) that specifically bound the URE was cloned from a rat brain cDNA library using the URE-containing oligonucleotide. Recombinantly expressed, affinity purified UreB1 protein retains specific binding to the URE oligonucleotide. UreB1 contains a tyrosine kinase phosphorylation consensus and binding is enhanced following phosphorylation with the p43v-abl tyrosine kinase. The UreB1 tyrosine phosphoprotein increases transcription in vitro, consistent with a positive transcriptional regulatory function. UreB1 transcripts are well expressed in subsets of neurons in multiple brain areas suggesting that, in addition to regulation of the preprodynorphin gene, it may have a more generalized role in gene transcription. | lld:pubmed |
| pubmed-article:7968380 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7968380 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7968380 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7968380 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7968380 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:7968380 | pubmed:issn | 0169-328X | lld:pubmed |
| pubmed-article:7968380 | pubmed:author | pubmed-author:RehEE | lld:pubmed |
| pubmed-article:7968380 | pubmed:author | pubmed-author:DubnerRR | lld:pubmed |
| pubmed-article:7968380 | pubmed:author | pubmed-author:IadarolaM JMJ | lld:pubmed |
| pubmed-article:7968380 | pubmed:author | pubmed-author:HUII | lld:pubmed |
| pubmed-article:7968380 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7968380 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:7968380 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7968380 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7968380 | pubmed:pagination | 77-88 | lld:pubmed |
| pubmed-article:7968380 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:7968380 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7968380 | pubmed:articleTitle | Cloning of a DNA binding protein that is a tyrosine kinase substrate and recognizes an upstream initiator-like sequence in the promoter of the preprodynorphin gene. | lld:pubmed |
| pubmed-article:7968380 | pubmed:affiliation | Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892. | lld:pubmed |
| pubmed-article:7968380 | pubmed:publicationType | Journal Article | lld:pubmed |
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