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rdf:type |
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lifeskim:mentions |
umls-concept:C0022646,
umls-concept:C0027713,
umls-concept:C0034693,
umls-concept:C0205164,
umls-concept:C0243163,
umls-concept:C0443252,
umls-concept:C0450127,
umls-concept:C0699914,
umls-concept:C1274040,
umls-concept:C1521761,
umls-concept:C1561604,
umls-concept:C1999230
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pubmed:issue |
5
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pubmed:dateCreated |
1994-12-2
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pubmed:abstractText |
The effects of augmenting the nephron supply on indices of allograft injury were assessed in a rat model of "chronic rejection." Orthotopic renal allotransplantation into unine-phrectomized rats was followed by excision (allograft-alone group) or preservation of the remaining native kidney (allograft+native kidney group) such that the total kidney complement was either the allograft alone, or the allograft plus one retained native kidney. After 18 wk, values for GFR (1.85 +/- 0.3 ml/min) and kidney weights (2.3 +/- 0.2 g) in allograft-alone rats were far in excess of corresponding values in the allograft of allograft+native kidney rats (0.88 +/- 0.1 ml/min and 1.1 +/- 0.5 g, respectively). Proteinuria (35 +/- 2 mg/d) and allograft glomerulosclerosis (24 +/- 8%) also characterized allograft-alone but not allograft+native kidney rats, in whom glomerular structure (allograft glomerulosclerosis, 4 +/- 1%; native kidney glomerulosclerosis, 0%) and glomerular functional integrity (proteinuria 7 +/- 0.7 mg/d) were well preserved. Thus, the observed allograft protection derived from the presence of a retained recipient native kidney supports the hypothesis that a single renal allograft contains insufficient nephrons to prevent progressive renal injury, implicating nephron supply as a major determinant of long-term allograft outcome.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7962562-13233354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7962562-1391717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7962562-14046168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7962562-1412763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7962562-1546799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7962562-1593854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7962562-1680253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7962562-1949166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7962562-1987682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7962562-1990556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7962562-2103160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7962562-2103167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7962562-2301899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7962562-2658558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7962562-2875240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7962562-3753571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7962562-4928429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7962562-6336299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7962562-6337479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7962562-7246778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7962562-7379260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7962562-8105570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7962562-8333067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7962562-8475548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7962562-8494022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7962562-8497913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7962562-874633
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
94
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2148-52
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7962562-Animals,
pubmed-meshheading:7962562-Glomerular Filtration Rate,
pubmed-meshheading:7962562-Glomerulosclerosis, Focal Segmental,
pubmed-meshheading:7962562-Kidney Transplantation,
pubmed-meshheading:7962562-Male,
pubmed-meshheading:7962562-Nephrons,
pubmed-meshheading:7962562-Proteinuria,
pubmed-meshheading:7962562-Rats,
pubmed-meshheading:7962562-Rats, Inbred F344,
pubmed-meshheading:7962562-Rats, Inbred Lew,
pubmed-meshheading:7962562-Transplantation, Homologous
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pubmed:year |
1994
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pubmed:articleTitle |
Nephron supply is a major determinant of long-term renal allograft outcome in rats.
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pubmed:affiliation |
Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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