Linked Life Data

7959604

Source:http://linkedlifedata.com/resource/pubmed/id/7959604

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1994-12-28
pubmed:abstractText
An immunoradiometric assay (IRMA) of human hemoglobin-haptoglobin complex (Hb-Hp complex) was established for the purpose of clinical application as a new fecal occult blood test. This IRMA reacted with free human Hb and Hp as well as Hb-Hp complex and its measurable range was 3.125 through 800 ng/ml. Its cross-reaction with other animal Hb and serum was little enough to neglect. The immunoreactivity of Hb-Hp complex was more stable than that of free Hb in incubation with gastric juice and fecal extracts. Of 48 stools from the patients with colorectal cancer, 44 (91.7%) gave positive (above 10 ng/ml in fecal extract) test in Hb-Hp complex-IRMA, whereas 35 (72.9%) (p < 0.05) gave positive result (above 10 ng/ml in fecal extract) in Hb-IRMA. At proximal site of cancer, positive rate of Hb-Hp complex in feces was significantly high (p < 0.05) compared with Hb. Of 64 stools from the patients with colorectal adenomas, 56 (87.5%) gave positive test in Hb-Hp complex, whereas 46 (71.9%) (p < 0.05), 28 (43.8%) (p < 0.01) and 33 (51.5%) showed positive in Hp, Hb and Guaiac test, respectively. In every size and site of adenoma, fecal Hb-Hp complex showed significantly high (p < 0.01) positivity compared with Hb and Guaiac test. These results suggest that the measurement of Hb-Hp complex in fecal extracts may be a useful tool for the early detection of lower gastrointestinal diseases.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0367-6102
pubmed:author
pubmed:issnType
Print
pubmed:volume
69
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
995-1009
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
[Measurement of fecal hemoglobin-haptoglobin complex as a new diagnostic tool of lower gastrointestinal tract diseases].
pubmed:affiliation
Third Department of Internal Medicine, Hokkaido University School of Medicine, Sapporo, Japan.
pubmed:publicationType
Journal Article, English Abstract