Linked Life Data

7953532

Source:http://linkedlifedata.com/resource/pubmed/id/7953532

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1994-12-2
pubmed:abstractText
Helper T-cell activation is initiated in vivo when the T-cell receptor complex recognizes an antigen fragment associated with MHC class II molecules on the surface of an antigen-presenting cell. In most previous studies of this phenomenon, T cells were stimulated not with antigen-presenting cells, but with CD3-specific antibodies. This approach provided considerable understanding of the cascade of molecular events triggered by T-cell receptor stimulation. However, the specific consequences of cell-cell interactions are still poorly understood. We therefore used a dual imaging system that provides simultaneous transmission and fluorescence images to study the morphological changes and variations of intracellular calcium concentration ([Ca2+]i) triggered in a human CD4+ antigen-specific T-cell clone in response to antigen presented by a class II-transfected murine fibroblast.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0960-9822
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
584-95
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Antigen recognition by helper T cells elicits a sequence of distinct changes of their shape and intracellular calcium.
pubmed:affiliation
Laboratoire de Neurobiologie, CNRS URA 1857, Ecole Normale Supérieure, Paris, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't