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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1994-12-2
|
| pubmed:abstractText |
The T lymphocyte function in 59 patients with malignant biliary obstruction undergoing pre-operative endoscopic drainage (group Ia, n = 24) or surgery (group Ib, n = 35) was evaluated by mitogen stimulation test with phytohaemagglutinin. The T lymphocyte function before endoscopic or surgical intervention was found to be impaired as compared with patients with gastric cancer (group II, n = 27) and with normal persons (group III, n = 19). Regression analysis showed a significant negative correlation between T lymphocyte function and the serum bilirubin level (correlation coefficient -0.3, P = 0.01) and a positive correlation with serum albumin level (correlation coefficient 0.34, P = 0.01) and serum transferrin level (correlation coefficient 0.45, P = 0.001). After 18 +/- 3 days of endoscopic biliary drainage, the T lymphocyte function of group Ia patients did not change substantially. At postoperative day 14, there were more patients in both groups Ia and Ib having deterioration of T lymphocyte function than those with improvement. The incidence of postoperative sepsis was found to be significantly higher in patients with deterioration than those with improvement of T lymphocyte function (18/31 vs 7/26, P = 0.036). It is concluded that endoscopic biliary drainage and surgery could not reverse the T lymphocyte dysfunction in patients with malignant biliary obstruction.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0815-9319
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
391-5
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7948822-Aged,
pubmed-meshheading:7948822-Bile Duct Neoplasms,
pubmed-meshheading:7948822-Cholestasis,
pubmed-meshheading:7948822-Drainage,
pubmed-meshheading:7948822-Humans,
pubmed-meshheading:7948822-Incidence,
pubmed-meshheading:7948822-Lymphocyte Activation,
pubmed-meshheading:7948822-Middle Aged,
pubmed-meshheading:7948822-Postoperative Complications,
pubmed-meshheading:7948822-Sepsis,
pubmed-meshheading:7948822-Stomach Neoplasms,
pubmed-meshheading:7948822-T-Lymphocytes
|
| pubmed:articleTitle |
T lymphocyte function in patients with malignant biliary obstruction.
|
| pubmed:affiliation |
Department of Surgery, University of Hong Kong, Queen Mary Hospital.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
|