Linked Life Data

7948188

Source:http://linkedlifedata.com/resource/pubmed/id/7948188

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1994-12-20
pubmed:abstractText
A method based on high-performance liquid chromatography (HPLC) was developed to study degraded chloroquine samples produced after exposure to sunlight in the Sudan. The method was also used to investigate chloroquine photodegradation after irradiation by UV and sunlight at ambient temperature. The study showed that the photodecomposition of chloroquine was pH and solvent dependent. Moreover, the extent of reaction was found to increase in the absence of oxygen. At pH 8, where the reaction rate was high, the photodecomposition was found to follow pseudo-first-order reaction kinetics. The HPLC method developed was also employed to analyse chloroquine and its degradation products in two commercially available brands of chloroquine injections which had been stored under local conditions in the Sudan. A number of degradation products were separated and examined by photodiode array spectroscopy and preparative TLC.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0731-7085
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
667-74
pubmed:dateRevised
2000-12-18
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Photodegradation studies on chloroquine phosphate by high-performance liquid chromatography.
pubmed:affiliation
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Khartoum, Sudan.
pubmed:publicationType
Journal Article