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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1994-12-22
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pubmed:abstractText |
In 31 cases of chronic myelogenous leukaemia (CML) we examined the prognostic significance of chromosomal loss of a 17p and p53 mutations at the onset of blast crisis (BC). p53 mutations were closely related to a shortened survival in CML-BC (P < 0.005 by the logrank test), whereas loss of a 17p by itself was not a poor prognostic indicator. The prognostic significance of loss of a 17p, however, emerged when combined with its predominance in the metaphases analysed. This predominance might easily and rapidly be screened by polymerase chain reaction-based analysis in about half of the cases.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0007-1048
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
425-7
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:7947294-Adolescent,
pubmed-meshheading:7947294-Adult,
pubmed-meshheading:7947294-Aged,
pubmed-meshheading:7947294-Blast Crisis,
pubmed-meshheading:7947294-Chromosome Deletion,
pubmed-meshheading:7947294-Chromosomes, Human, Pair 17,
pubmed-meshheading:7947294-Genes, p53,
pubmed-meshheading:7947294-Humans,
pubmed-meshheading:7947294-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:7947294-Middle Aged,
pubmed-meshheading:7947294-Mutation,
pubmed-meshheading:7947294-Polymerase Chain Reaction,
pubmed-meshheading:7947294-Prognosis
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pubmed:year |
1994
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pubmed:articleTitle |
Prognostic significance of loss of a chromosome 17p and p53 gene mutations in blast crisis of chronic myelogenous leukaemia.
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pubmed:affiliation |
Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
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pubmed:publicationType |
Journal Article
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