Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
21
pubmed:dateCreated
1994-11-10
pubmed:abstractText
Transgenic (Tg) mice were constructed that express a chimeric prion protein (PrP) in which a segment of mouse (Mo) PrP was replaced with the corresponding human (Hu) PrP sequence. The chimeric PrP, designated MHu2MPrP, differs from MoPrP by 9 amino acids between residues 96 and 167. All of the Tg(MHu2M) mice developed neurologic disease approximately 200 days after inoculation with brain homogenates from three patients dying of Creutzfeldt-Jakob disease (CJD). Inoculation of Tg(MHu2M) mice with CJD prions produced MHu2MPrPSc (where PrPSc is the scrapie isoform of PrP); inoculation with Mo prions produced Mo-PrPSc. The patterns of MHu2MPrPSc and MoPrPSc accumulation in the brains of Tg(MHu2M) mice were different. About 10% of Tg(HuPrP) mice expressing HuPrP and non-Tg mice developed neurologic disease > 500 days after inoculation with CJD prions. The different susceptibilities of Tg(HuPrP) and Tg(MHu2M) mice to Hu prions indicate that additional species-specific factors are involved in prion replication. Diagnosis, prevention, and treatment of Hu prion diseases should be facilitated by Tg(MHu2M) mice.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-1291035, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-1338978, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-1346338, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-1350920, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-1354357, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-1356161, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-1363810, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-13692303, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-1469410, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-1628828, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-1674116, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-1675319, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-1719082, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-1744660, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-1967489, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-1977523, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-1992185, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-2025705, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-2199610, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-2446004, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-2468821, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-2564168, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-2572197, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-2574076, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-2873895, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-3015416, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-3054015, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-3066847, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-3090160, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-3112607, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-3295589, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-3462700, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-356055, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-3755672, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-388439, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-3897861, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-5661299, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-5922150, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-6791762, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-7902565, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-7902575, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-7908088, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-7911243, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-7913989, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-8098995, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-8100741, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-8101989, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-8113733, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-8179297, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-8309577, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-8400968, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-8419831, http://linkedlifedata.com/resource/pubmed/commentcorrection/7937921-8440932
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
91
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9936-40
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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