|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0008976,
umls-concept:C0011209,
umls-concept:C0013216,
umls-concept:C0016360,
umls-concept:C0023413,
umls-concept:C0027627,
umls-concept:C0030705,
umls-concept:C0034656,
umls-concept:C0069717,
umls-concept:C0439841,
umls-concept:C1527249,
umls-concept:C1547135,
umls-concept:C1547139,
umls-concept:C1561560,
umls-concept:C1561561
|
|
pubmed:issue |
21
|
|
pubmed:dateCreated |
1994-11-16
|
|
pubmed:abstractText |
In a previous phase II trial, circadian (chronomodulated) delivery of fluorouracil (5-FU), folinic acid (FA; leucovorin), and oxaliplatin (1-OHP; a new platinum complex with no renal and minor hematologic toxic effects) produced an objective response rate of 58% in 93 patients with metastatic colorectal cancer.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0027-8874
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
2
|
|
pubmed:volume |
86
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
N
|
|
pubmed:pagination |
1608-17
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:7932825-Adult,
pubmed-meshheading:7932825-Aged,
pubmed-meshheading:7932825-Ambulatory Care,
pubmed-meshheading:7932825-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:7932825-Circadian Rhythm,
pubmed-meshheading:7932825-Colorectal Neoplasms,
pubmed-meshheading:7932825-Drug Administration Schedule,
pubmed-meshheading:7932825-Female,
pubmed-meshheading:7932825-Fluorouracil,
pubmed-meshheading:7932825-Humans,
pubmed-meshheading:7932825-Leucovorin,
pubmed-meshheading:7932825-Male,
pubmed-meshheading:7932825-Middle Aged,
pubmed-meshheading:7932825-Organoplatinum Compounds,
pubmed-meshheading:7932825-Survival Analysis,
pubmed-meshheading:7932825-Treatment Outcome
|
|
pubmed:year |
1994
|
|
pubmed:articleTitle |
Chronomodulated versus fixed-infusion-rate delivery of ambulatory chemotherapy with oxaliplatin, fluorouracil, and folinic acid (leucovorin) in patients with colorectal cancer metastases: a randomized multi-institutional trial.
|
|
pubmed:affiliation |
Laboratoire Rythmes Biologiques et Chronothérapeutique, Hôpital Paul Brousse, Villejuif, France.
|
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
|
