Linked Life Data

7932038

Source:http://linkedlifedata.com/resource/pubmed/id/7932038

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-10-27
pubmed:abstractText
The role of melatonin on adrenal medullary function was evaluated in adult golden (Syrian) hamsters injected daily at either 0800 or 1600 with melatonin (25 micrograms/hamster) or vehicle (0.1% ethanol in saline). Sixty days after initiation of treatment and 16 or 24 hr after the last injection of melatonin, animals were killed by decapitation and blood and tissue collected. Plasma prolactin levels were reduced by chronic administration of melatonin only when animals were treated at 1600. Tyrosine hydroxylase (TH) activity in the adrenal medulla was not changed by either morning or afternoon administration of melatonin. Phenylethanolamine-N-methyl transferase (PNMT) was changed by afternoon administration of melatonin. Morning and afternoon melatonin injections led to the reduction of both adrenal monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT) activities although the afternoon injections led to a greater magnitude of change. Norepinephrine and epinephrine contents were significantly reduced by morning melatonin administration but were not changed by afternoon administration of the hormone. These data suggest that melatonin has direct and possibly indirect effects on adrenal medullary function in the hamster. However, further studies will be required to characterize the effects of melatonin on catecholamine synthesis and release and the physiological significance of these effects.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0742-3098
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
154-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Effects of chronic melatonin administration on adrenal medulla catecholamine metabolism in adult male golden hamsters.
pubmed:affiliation
Departamento de Bioquímica y Bioilogía, Molecular, Universidad Complutense, Madrid, Spain.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't