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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1994-10-24
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pubmed:abstractText |
The purpose of this prospective work was to study a possible relationship between autoantibodies, cryoglobulinaemia and liver histologic lesions in chronic hepatitis C. Ninety three patients (mean age: 43.3 years) with histologically proven chronic hepatitis were studied. Chronic hepatitis was associated with cirrhosis in 18 cases. Auto-antibodies detection was performed in the serum of all patients and cryoglobulinaemia detection was performed in 47 patients. The prevalence of auto-antibodies was also studied in 45 blood donors (control group) and 30 patients with chronic hepatitis B. Histologic study included Knodell score and semi-quantitatively expressed histologic lesions considered as more specific of chronic hepatitis C. Twenty six of the 93 patients (28%) had at least an autoantibody with a level > or = 1/100. The autoantibodies prevalence was: smooth muscle: 15%, antinuclear: 15%, LKM 1: 1.2%, mitochondrial: 0. A mixed cryoglobulinaemia was present in 23 of 47 patients (49%). The prevalence of anti-smooth-muscle autoantibodies was significantly increased in hepatitis C patients compared with the control group (P < 0.05). The histologic Knodell score was 7.3 +/- 3.6. The histologic lesion prevalence was: portal tract lymphoid follicles: 97%, acidophil bodies: 85%, intra-sinusoidal lymphoid infiltrates: 71%, steatosis: 61%, microgranulomas: 54%, biliary duct tract damages: 53%. No statistical significant correlation was found between autoantibodies prevalence and liver histologic lesions. The Knodell score was only significantly increased in patients with mixed cryoglobulinaemia (8.4 +/- 3.6 vs 6.2 +/- 2.8) (P < 0.05). These results suggest that the autoantibodies presence in chronic hepatitis C does not change hepatic histologic lesions.(ABSTRACT TRUNCATED AT 250 WORDS)
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pubmed:language |
fre
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0399-8320
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
251-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7926441-Adult,
pubmed-meshheading:7926441-Aged,
pubmed-meshheading:7926441-Antibodies, Antinuclear,
pubmed-meshheading:7926441-Autoantibodies,
pubmed-meshheading:7926441-Cryoglobulinemia,
pubmed-meshheading:7926441-Female,
pubmed-meshheading:7926441-Hepatitis, Chronic,
pubmed-meshheading:7926441-Hepatitis B,
pubmed-meshheading:7926441-Hepatitis C,
pubmed-meshheading:7926441-Humans,
pubmed-meshheading:7926441-Liver Cirrhosis,
pubmed-meshheading:7926441-Male,
pubmed-meshheading:7926441-Middle Aged,
pubmed-meshheading:7926441-Mitochondria, Liver,
pubmed-meshheading:7926441-Muscle, Smooth,
pubmed-meshheading:7926441-Prospective Studies,
pubmed-meshheading:7926441-Reference Values
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pubmed:year |
1994
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pubmed:articleTitle |
[Is there a relationship between the presence of autoantibodies or mixed cryoglobulinemia and the clinical and histological characteristics of chronic viral hepatitis C?].
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pubmed:affiliation |
Clinique d'Hépato-Gastroentérologie, CHU, Grenoble.
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pubmed:publicationType |
Journal Article,
English Abstract
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