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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1994-11-3
|
| pubmed:abstractText |
Interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-alpha) have been implicated as immune effector molecules in the pathogenesis of insulin-dependent diabetes mellitus (IDDM). Recently, an increased frequency of the A1/A1 genotype of an IL-1 receptor antagonist (IL-1Ra) gene polymorphism was observed in patients with IDDM. Therefore, we investigated plasma IL-1Ra and soluble TNF p55 receptor (TNFsRp55) levels in 18 men with recent-onset IDDM, 10 men with long-standing IDDM, and 35 age-matched healthy men. No differences in plasma IL-1Ra were found among the three groups. However, when the plasma IL-1Ra levels in the subjects with IDDM and the control subjects were analyzed according to IL-1Ra genotypes, we found a 30% lower level of plasma IL-1Ra in subjects with IDDM carrying the A1/A1 genotype compared with the levels in those carrying the A1/A2 genotype (372 +/- 40 vs. 530 +/- 54 ng/l, respectively, P = 0.025). In contrast, no significant association was seen between plasma IL-1Ra and IL-1Ra genotype in the control subjects. The TNFsRp55 level in heparinized plasma was 17% lower in patients with IDDM than in control subjects (3.93 +/- 0.22 vs. 4.72 +/- 0.24 micrograms/l, respectively, P = 0.038). These findings could not be explained by metabolic derangement in the IDDM patients.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/IL1RN protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin 1 Receptor Antagonist...,
http://linkedlifedata.com/resource/pubmed/chemical/Monokines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Sialoglycoproteins
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0012-1797
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
43
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1242-7
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7926295-Adult,
pubmed-meshheading:7926295-Base Sequence,
pubmed-meshheading:7926295-Blood Glucose,
pubmed-meshheading:7926295-DNA Primers,
pubmed-meshheading:7926295-Diabetes Mellitus, Type 1,
pubmed-meshheading:7926295-Genotype,
pubmed-meshheading:7926295-Humans,
pubmed-meshheading:7926295-Interleukin 1 Receptor Antagonist Protein,
pubmed-meshheading:7926295-Leukocyte Count,
pubmed-meshheading:7926295-Male,
pubmed-meshheading:7926295-Molecular Sequence Data,
pubmed-meshheading:7926295-Monokines,
pubmed-meshheading:7926295-Polymerase Chain Reaction,
pubmed-meshheading:7926295-Polymorphism, Genetic,
pubmed-meshheading:7926295-Radioimmunoassay,
pubmed-meshheading:7926295-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:7926295-Reference Values,
pubmed-meshheading:7926295-Sialoglycoproteins
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Monokine antagonism is reduced in patients with IDDM.
|
| pubmed:affiliation |
Steno Diabetes Center, Gentofte, Denmark.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|