Linked Life Data

7924865

Source:http://linkedlifedata.com/resource/pubmed/id/7924865

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-11-2
pubmed:abstractText
The purpose of this study is to elucidate the effect of preoperative parenteral nutritional support (PNS) plus chemotherapy on tumor cell kinetics. 19 advanced gastric cancer (AGC) patients were divided into the following groups: group A (n = 7): in addition to their oral intake, received a PNS for 5 days, which yielded 117 Kj.kg-1.d-1 of non-protein calories and 0.15g.kg-1.d-1 of nitrogen. Group B(n = 6): were infused with 5-Fu at 8-10mg.kg-1.d-1 for 5 days and mitomycin C at 6-8mg.d-1 on the first and fifth day. Group C (n = 6): received a PNS plus 5-Fu with MMC as group A and B did. Specimens of gastric cancer and normal gastric mucosa were taken endoscopically before and after PNS. All specimens were studied by flow cytometry for cell cycle analysis. The results showed that the frequency of cells in S and proliferative phases were significantly increased after PNS (P < 0.01, P < 0.001), but decreased after PNS+chemotherapy (P < 0.05, P < 0.025). No significant change after single chemotherapy was observed. In conclusion, PNS might enhance the effect of chemotherapy in AGC patients, probably, by stimulation of tumor cell kinetics.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0253-3766
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
137-40
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
[Effects of preoperative parenteral nutritional support with chemotherapy on tumor cell kinetics in gastric cancer patients].
pubmed:affiliation
Department of Surgery, Ruijin Hospital, Shanghai Second Medical University.
pubmed:publicationType
Journal Article, Clinical Trial, English Abstract, Randomized Controlled Trial