Linked Life Data

7924071

Source:http://linkedlifedata.com/resource/pubmed/id/7924071

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-10-24
pubmed:abstractText
The suggestion that an alteration of the blood-brain barrier (BBB) is an obligatory step in the pathogenesis of the multiple sclerosis (MS) lesion has been amply confirmed by innumerable magnetic resonance scans. There also exists a large body of clinical, neuropathologic, neuropsychologic, radiologic and experimental evidence that shows that trauma, in particular mild concussive injury to the head, neck or upper back, thus impinging on the brain and spinal cord, may result in an increase in BBB permeability. It is only logical therefore to infer that when such mild trauma to those parts of the body affects MS patients, the resulting alteration of the BBB leads to the formation of new lesions or the enlargement and activation of old ones. In such situations trauma acts as a facilitator of the postulated but still not fully understood pathogenetic mechanism of lesion formation. Because of the extremely poor correlation between site and size of the lesions and clinical manifestations of MS, one cannot expect that every episode of trauma will result in the appearance of new symptoms in an hitherto asymptomatic individual, or the recurrence of old symptoms in an MS patient. It is inappropriate to attempt to prove or disprove a causal relationship between physical trauma and MS exacerbations or clinical onset by means of epidemiologic studies. The unpredictability and variability of the clinical manifestations of the disease, the differences in the genetic and immunologic backgrounds of individuals, as well as in their degree of clinical and pathologic involvement and level of activity, render such investigations pointless.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0303-8467
pubmed:author
pubmed:issnType
Print
pubmed:volume
96
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
103-10
pubmed:dateRevised
2009-10-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
The role of trauma in the pathogenesis of multiple sclerosis: a review.
pubmed:affiliation
Department of Neurology, Harvard Medical School, Boston, MA 02215.
pubmed:publicationType
Journal Article, Review