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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1994-10-31
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pubmed:databankReference |
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pubmed:abstractText |
The products of plant disease resistance genes are postulated to recognize invading pathogens and rapidly trigger host defense responses. Here we describe isolation of the resistance gene N of tobacco that mediates resistance to the viral pathogen tobacco mosaic virus (TMV). The N gene was isolated by transposon tagging using the maize Activator transposon. A genomic DNA fragment containing the N gene conferred TMV resistance to TMV susceptible tobacco. Sequence analysis of the N gene shows that it encodes a protein of 131.4 kDa with an amino-terminal domain similar to that of the cytoplasmic domain of the Drosophila Toll protein and the interleukin-1 receptor (IL-1R) in mammals, a nucleotide-binding site (NBS), and 14 [corrected] imperfect leucine-rich repeats (LRR). The sequence similarity of N, Toll, and IL-1R suggests that N mediates rapid gene induction and TMV resistance through a Toll-IL-1-like pathway.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/N protein, Nicotiana glutinosa,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Tl protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptors
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
78
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pubmed:geneSymbol |
N
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1101-15
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:7923359-Amino Acid Sequence,
pubmed-meshheading:7923359-Base Sequence,
pubmed-meshheading:7923359-Cloning, Molecular,
pubmed-meshheading:7923359-DNA, Complementary,
pubmed-meshheading:7923359-Drosophila Proteins,
pubmed-meshheading:7923359-Genes, Plant,
pubmed-meshheading:7923359-Genetic Complementation Test,
pubmed-meshheading:7923359-Genomic Library,
pubmed-meshheading:7923359-Immunity, Innate,
pubmed-meshheading:7923359-Insect Hormones,
pubmed-meshheading:7923359-Membrane Glycoproteins,
pubmed-meshheading:7923359-Models, Genetic,
pubmed-meshheading:7923359-Molecular Sequence Data,
pubmed-meshheading:7923359-Mutagenesis, Insertional,
pubmed-meshheading:7923359-Plant Diseases,
pubmed-meshheading:7923359-Plant Proteins,
pubmed-meshheading:7923359-Plants, Genetically Modified,
pubmed-meshheading:7923359-Plants, Toxic,
pubmed-meshheading:7923359-Receptors, Cell Surface,
pubmed-meshheading:7923359-Receptors, Interleukin-1,
pubmed-meshheading:7923359-Sequence Analysis, DNA,
pubmed-meshheading:7923359-Sequence Homology, Amino Acid,
pubmed-meshheading:7923359-Signal Transduction,
pubmed-meshheading:7923359-Tobacco,
pubmed-meshheading:7923359-Tobacco Mosaic Virus,
pubmed-meshheading:7923359-Toll-Like Receptors,
pubmed-meshheading:7923359-Virus Diseases
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pubmed:year |
1994
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pubmed:articleTitle |
The product of the tobacco mosaic virus resistance gene N: similarity to toll and the interleukin-1 receptor.
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pubmed:affiliation |
Department of Plant Pathology, University of California, Berkeley 94720.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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