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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
7
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pubmed:dateCreated |
1994-11-8
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pubmed:abstractText |
Placentas of women suffering from pregnancy-induced hypertension (PIH) were found to contain a greater amount of Na,K-ATPase molecules, estimated from anthroyl ouabain binding, than normotensive individuals. Both the microsomal fraction of placental cells and purified Na,K-ATPase showed an increased affinity for the specific inhibitor ouabain which, in the case of the microsomes, bound with a dissociation constant of 0.9 nM as compared with 3.4 nM in the controls. Likewise, the dissociation constant of the ouabain complex with purified Na,K-ATPase was about 3.5 times lower in the hypertensive patients. The differences are apparently caused by a different microenvironment of the ouabain-binding site, as reflected in the quantum yield of bound anthroyl ouabain. If an endogenous digitalis-like factor is present in the body fluids to regulate Na,K-ATPase activity, the present results render its role quite plausible.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1065-6995
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
pubmed:pagination |
723-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7920379-Adult,
pubmed-meshheading:7920379-Cardiac Glycosides,
pubmed-meshheading:7920379-Female,
pubmed-meshheading:7920379-Humans,
pubmed-meshheading:7920379-Hypertension,
pubmed-meshheading:7920379-Microsomes,
pubmed-meshheading:7920379-Ouabain,
pubmed-meshheading:7920379-Placenta,
pubmed-meshheading:7920379-Pregnancy,
pubmed-meshheading:7920379-Pregnancy Complications, Cardiovascular
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pubmed:year |
1994
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pubmed:articleTitle |
Human hypertensive placenta contains an increased amount of Na,K-ATPase with higher affinity for cardiac glycosides.
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pubmed:affiliation |
Institute of Physiology, CzAcadSci, Prague, Czech Republic.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|