rdf:type |
|
lifeskim:mentions |
umls-concept:C0001675,
umls-concept:C0023828,
umls-concept:C0065610,
umls-concept:C0129341,
umls-concept:C0205179,
umls-concept:C0225317,
umls-concept:C0282460,
umls-concept:C1257890,
umls-concept:C1261473,
umls-concept:C1516985,
umls-concept:C1704327,
umls-concept:C2603343
|
pubmed:issue |
6
|
pubmed:dateCreated |
1994-11-8
|
pubmed:abstractText |
The EORTC Soft Tissue and Bone Sarcoma Group conducted a phase II study with intravenous muramyl tripeptide phosphatidylethanolamine (MTP/PE) at a dose of 4 mg once weekly in 20 patients with metastatic soft tissue sarcomas. Responses were not seen in 19 evaluable patients. Toxicity consisted mainly of a mild flu-like syndrome after 62% of drug administrations. It is concluded that MTP/PE at this dose and schedule has no activity in metastatic soft tissue sarcoma.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:issn |
0959-8049
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
30A
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
842-3
|
pubmed:dateRevised |
2006-5-17
|
pubmed:meshHeading |
pubmed-meshheading:7917546-Acetylmuramyl-Alanyl-Isoglutamine,
pubmed-meshheading:7917546-Adult,
pubmed-meshheading:7917546-Aged,
pubmed-meshheading:7917546-Antineoplastic Agents,
pubmed-meshheading:7917546-Drug Carriers,
pubmed-meshheading:7917546-Female,
pubmed-meshheading:7917546-Humans,
pubmed-meshheading:7917546-Liposomes,
pubmed-meshheading:7917546-Male,
pubmed-meshheading:7917546-Middle Aged,
pubmed-meshheading:7917546-Phosphatidylethanolamines,
pubmed-meshheading:7917546-Sarcoma,
pubmed-meshheading:7917546-Soft Tissue Neoplasms
|
pubmed:year |
1994
|
pubmed:articleTitle |
Phase II study of liposomal muramyl tripeptide phosphatidylethanolamine (MTP/PE) in advanced soft tissue sarcomas of the adult. An EORTC Soft Tissue and Bone Sarcoma Group study.
|
pubmed:affiliation |
Department of Medical Oncology, Rotterdam Cancer Institute, The Netherlands.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Clinical Trial, Phase II
|