rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
4
|
pubmed:dateCreated |
1993-9-27
|
pubmed:databankReference |
|
pubmed:abstractText |
The chick homeobox gene goosecoid (gsc) is first expressed in a barely noticeable cell population near the posterior margin (Koller's sickle) of the unincubated egg. Then it is detected in Hensen's node, traditionally considered the chick organizer. Later, gsc-expressing cells leave the node with the prechordal plate. Fate mapping indicates that these three regions are related by cell lineage, and transplantation experiments suggest that they all have inducing activity. Quail posterior margin and anterior primitive streak grafts (gsc expressing) induce gsc transcription in neighboring chick host cells. We propose that development of the chick organizer starts earlier than previously thought and that gsc marks this changing cell population.
|
pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
0092-8674
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
27
|
pubmed:volume |
74
|
pubmed:geneSymbol |
gsc
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
645-59
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:7916659-Amino Acid Sequence,
pubmed-meshheading:7916659-Animals,
pubmed-meshheading:7916659-Blastoderm,
pubmed-meshheading:7916659-Chick Embryo,
pubmed-meshheading:7916659-Chickens,
pubmed-meshheading:7916659-Embryonic and Fetal Development,
pubmed-meshheading:7916659-Gene Expression,
pubmed-meshheading:7916659-Genes, Homeobox,
pubmed-meshheading:7916659-In Situ Hybridization,
pubmed-meshheading:7916659-Mice,
pubmed-meshheading:7916659-Molecular Sequence Data,
pubmed-meshheading:7916659-Oocytes,
pubmed-meshheading:7916659-Plasmids,
pubmed-meshheading:7916659-Quail,
pubmed-meshheading:7916659-Sequence Homology, Amino Acid,
pubmed-meshheading:7916659-Transcription, Genetic,
pubmed-meshheading:7916659-Xenopus
|
pubmed:year |
1993
|
pubmed:articleTitle |
The homeobox gene goosecoid and the origin of organizer cells in the early chick blastoderm.
|
pubmed:affiliation |
Molecular Biology Institute, University of California, Los Angeles 90024-1737.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|