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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8922
|
pubmed:dateCreated |
1994-9-22
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pubmed:abstractText |
Biliary stents are liable to clog. We investigated whether a choleretic plus an antibiotic could delay clogging. 20 consecutive patients with a malignant biliary stricture were randomised after endoscopic insertion of a polyethylene stent to receive ursodeoxycholic acid plus norfloxacin (13-15 mg/kg and 400 mg, daily) or conservative treatment. The drug combination was associated with: a longer median patency of first (49 vs 6 weeks) and all stents (38 vs 7 weeks); a prolonged median survival (67 vs 18 weeks); and a shorter mean hospital stay (0.2 vs 1.0 days per week of survival). Thus ursodeoxycholic acid plus norfloxacin may prevent stent clogging.
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pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
0140-6736
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
27
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pubmed:volume |
344
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
581-2
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:7914962-Administration, Oral,
pubmed-meshheading:7914962-Bile Ducts,
pubmed-meshheading:7914962-Cholestasis,
pubmed-meshheading:7914962-Constriction, Pathologic,
pubmed-meshheading:7914962-Drug Therapy, Combination,
pubmed-meshheading:7914962-Humans,
pubmed-meshheading:7914962-Norfloxacin,
pubmed-meshheading:7914962-Stents,
pubmed-meshheading:7914962-Ursodeoxycholic Acid
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pubmed:year |
1994
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pubmed:articleTitle |
Randomised trial of prevention of biliary stent occlusion by ursodeoxycholic acid plus norfloxacin.
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pubmed:affiliation |
Hepatology Unit, University Hospital, Poitiers, France.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|