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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1994-6-23
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pubmed:databankReference |
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pubmed:abstractText |
The F17b fimbriae encoded by the transmissible virulence plasmid Vir, also coding for cytotoxic necrotizing factor type 2, were characterized. A 5.7-kb region of Vir mediates in vitro N-acetylglucosamine-sensitive adhesion to calf intestinal villi. Sequence analysis revealed that this region codes for a structural subunit and an adhesin closely related to the F17-A and F17-G proteins encoded by the F17 fimbrial gene cluster. The F17b-A gene presents an open reading frame of 540 bp encoding a polypeptide of 180 amino acids with a putative signal peptide of 21 residues. The mature protein shows an identity of 74% with the F17-A structural subunit. This 20-kDa protein is recognized by antiserum directed against F17 fimbriae. The F17b-G gene shows an open reading frame of 1,029 bp encoding a polypeptide of 343 amino acids with a putative signal peptide of 22 residues. The F17b-G polypeptide exhibits 95% identity with the F17-G adhesin. The functional homology of the gene products was further confirmed by demonstrating that mutants in the F17-A gene can be complemented by the F17b-A gene and vice versa. These results prove that fimbriae belonging to the F17 family are also found on pathogenic Escherichia coli strains other than enterotoxigenic isolates producing heat-labile or heat-stable enterotoxin.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7910597-1563758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7910597-1675211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7910597-1774259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7910597-2001995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7910597-2185259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7910597-2187741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7910597-2438693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7910597-2656399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7910597-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7910597-2862689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7910597-2880835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7910597-2897333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7910597-2907846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7910597-2985470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7910597-3326246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7910597-3714490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7910597-388439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7910597-4606141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7910597-4896022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7910597-5327803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7910597-5432063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7910597-6138394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7910597-6167991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7910597-6757381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7910597-6988390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7910597-6996544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7910597-7006481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7910597-773832
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adhesins, Escherichia coli,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Outer Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Toxins,
http://linkedlifedata.com/resource/pubmed/chemical/Cytotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Escherichia coli Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Virulence Factors,
http://linkedlifedata.com/resource/pubmed/chemical/cytotoxic necrotizing factor type 1
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2633-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7910597-Adhesins, Escherichia coli,
pubmed-meshheading:7910597-Amino Acid Sequence,
pubmed-meshheading:7910597-Antigens, Bacterial,
pubmed-meshheading:7910597-Bacterial Outer Membrane Proteins,
pubmed-meshheading:7910597-Bacterial Proteins,
pubmed-meshheading:7910597-Bacterial Toxins,
pubmed-meshheading:7910597-Base Sequence,
pubmed-meshheading:7910597-Cytotoxins,
pubmed-meshheading:7910597-Escherichia coli,
pubmed-meshheading:7910597-Escherichia coli Proteins,
pubmed-meshheading:7910597-Fimbriae, Bacterial,
pubmed-meshheading:7910597-Molecular Sequence Data,
pubmed-meshheading:7910597-Plasmids,
pubmed-meshheading:7910597-Virulence Factors
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pubmed:year |
1994
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pubmed:articleTitle |
F17-like fimbriae from an invasive Escherichia coli strain producing cytotoxic necrotizing factor type 2 toxin.
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pubmed:affiliation |
Laboratorium Genetische Virologie, Vrije Universiteit Brussel, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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