| pubmed-article:7909989 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7909989 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:7909989 | lifeskim:mentions | umls-concept:C0019904 | lld:lifeskim |
| pubmed-article:7909989 | lifeskim:mentions | umls-concept:C0036341 | lld:lifeskim |
| pubmed-article:7909989 | lifeskim:mentions | umls-concept:C0082341 | lld:lifeskim |
| pubmed-article:7909989 | lifeskim:mentions | umls-concept:C1335671 | lld:lifeskim |
| pubmed-article:7909989 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7909989 | pubmed:dateCreated | 1994-6-8 | lld:pubmed |
| pubmed-article:7909989 | pubmed:abstractText | We have reported an association between schizophrenia and homozygosity of a Bal I polymorphism in the first exon of the dopamine D3 receptor gene (Crocq et al.: Journal of Medical Genetics 29:858-860, 1992). The present study consists of an attempt to replicate this finding in a further sample of 66 patients and 97 controls. Once again more patients than controls were homozygous, but the effect was not as strong as in our first study (chi 2 = 2.53, P = 0.05, one tailed). When pooled data from our two studies were analysed, excess homozygosity in patients remained highly significant (P = 0.002) with a particular excess of the 1:1 genotype (P = 0.01). This reflected a departure from Hardy-Weinberg equilibrium in the patients (P = 0.0005) but not the controls (P = 0.24). This led us to explore the possibility that there might be important differences between the patients in our two studies and that excess homozygosity might be a characteristic of particular subgroups of schizophrenics. Our findings suggest that the effect is consistently at its strongest in those patients who have a high familial loading and in those who have a good response to neuroleptic treatment, and that differences between our two samples might have contributed to the quantitatively different outcomes. | lld:pubmed |
| pubmed-article:7909989 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7909989 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7909989 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7909989 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7909989 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:7909989 | pubmed:issn | 0148-7299 | lld:pubmed |
| pubmed-article:7909989 | pubmed:author | pubmed-author:NIWACC | lld:pubmed |
| pubmed-article:7909989 | pubmed:author | pubmed-author:WilliamsJJ | lld:pubmed |
| pubmed-article:7909989 | pubmed:author | pubmed-author:McGuffinPP | lld:pubmed |
| pubmed-article:7909989 | pubmed:author | pubmed-author:ManuSS | lld:pubmed |
| pubmed-article:7909989 | pubmed:author | pubmed-author:AshersonPP | lld:pubmed |
| pubmed-article:7909989 | pubmed:author | pubmed-author:ParfittEE | lld:pubmed |
| pubmed-article:7909989 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7909989 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:7909989 | pubmed:volume | 54 | lld:pubmed |
| pubmed-article:7909989 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7909989 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7909989 | pubmed:pagination | 21-6 | lld:pubmed |
| pubmed-article:7909989 | pubmed:dateRevised | 2008-9-4 | lld:pubmed |
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| pubmed-article:7909989 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7909989 | pubmed:articleTitle | Relationship between homozygosity at the dopamine D3 receptor gene and schizophrenia. | lld:pubmed |
| pubmed-article:7909989 | pubmed:affiliation | Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom. | lld:pubmed |
| pubmed-article:7909989 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7909989 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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