|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1994-6-8
|
|
pubmed:abstractText |
We have reported an association between schizophrenia and homozygosity of a Bal I polymorphism in the first exon of the dopamine D3 receptor gene (Crocq et al.: Journal of Medical Genetics 29:858-860, 1992). The present study consists of an attempt to replicate this finding in a further sample of 66 patients and 97 controls. Once again more patients than controls were homozygous, but the effect was not as strong as in our first study (chi 2 = 2.53, P = 0.05, one tailed). When pooled data from our two studies were analysed, excess homozygosity in patients remained highly significant (P = 0.002) with a particular excess of the 1:1 genotype (P = 0.01). This reflected a departure from Hardy-Weinberg equilibrium in the patients (P = 0.0005) but not the controls (P = 0.24). This led us to explore the possibility that there might be important differences between the patients in our two studies and that excess homozygosity might be a characteristic of particular subgroups of schizophrenics. Our findings suggest that the effect is consistently at its strongest in those patients who have a high familial loading and in those who have a good response to neuroleptic treatment, and that differences between our two samples might have contributed to the quantitatively different outcomes.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antipsychotic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/DRD3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxyribonucleases, Type II...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D3,
http://linkedlifedata.com/resource/pubmed/chemical/TGGCCA-specific type II...
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0148-7299
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
54
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
21-6
|
|
pubmed:dateRevised |
2008-9-4
|
|
pubmed:meshHeading |
pubmed-meshheading:7909989-Adult,
pubmed-meshheading:7909989-Alleles,
pubmed-meshheading:7909989-Antipsychotic Agents,
pubmed-meshheading:7909989-Base Sequence,
pubmed-meshheading:7909989-Case-Control Studies,
pubmed-meshheading:7909989-Chi-Square Distribution,
pubmed-meshheading:7909989-DNA Primers,
pubmed-meshheading:7909989-Deoxyribonucleases, Type II Site-Specific,
pubmed-meshheading:7909989-Female,
pubmed-meshheading:7909989-Gene Frequency,
pubmed-meshheading:7909989-Homozygote,
pubmed-meshheading:7909989-Humans,
pubmed-meshheading:7909989-Male,
pubmed-meshheading:7909989-Middle Aged,
pubmed-meshheading:7909989-Molecular Sequence Data,
pubmed-meshheading:7909989-Odds Ratio,
pubmed-meshheading:7909989-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:7909989-Receptors, Dopamine,
pubmed-meshheading:7909989-Receptors, Dopamine D2,
pubmed-meshheading:7909989-Receptors, Dopamine D3,
pubmed-meshheading:7909989-Reproducibility of Results,
pubmed-meshheading:7909989-Schizophrenia,
pubmed-meshheading:7909989-Sequence Analysis, DNA,
pubmed-meshheading:7909989-Sex Factors,
pubmed-meshheading:7909989-Treatment Outcome
|
|
pubmed:year |
1994
|
|
pubmed:articleTitle |
Relationship between homozygosity at the dopamine D3 receptor gene and schizophrenia.
|
|
pubmed:affiliation |
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
