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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8903
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pubmed:dateCreated |
1994-5-17
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pubmed:abstractText |
Because of the similar virological properties of HIV types 1 and 2, HIV-2 was assumed to be as infectious and capable of inducing AIDS as HIV-1. Seroepidemiological studies have shown significant rates of HIV-2 infection in West Africa, and surveys from other regions of the world indicate that the spread of HIV-2 infection continues. However the pathogenic potential of HIV-2 is considered to be lower than that of HIV-1. It is therefore important to understand the transmission properties of HIV-2 and its contribution to the AIDS pandemic. Since 1985, we have prospectively studied 1452 registered female prostitutes in Dakar, Senegal, with sequential evaluation of their antibody status to HIV-1 and HIV-2. During the study the overall incidence of HIV-1 and HIV-2 was the same (1.11 per 100 person-years of observation [pyo]). However, the annual incidence of HIV-1 increased substantially: there was a 1.4-fold increased risk per year and thus a 12-fold increase in risk over the entire study period. The incidence of HIV-2 remained stable, despite higher HIV-2 prevalence. In our population the heterosexual spread of HIV-2 is significantly slower than that of HIV-1, which strongly suggests differences in the viruses' infectivity potential.
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pubmed:grant |
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pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Africa,
http://linkedlifedata.com/resource/pubmed/keyword/Africa South Of The Sahara,
http://linkedlifedata.com/resource/pubmed/keyword/Behavior,
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Cohort Analysis,
http://linkedlifedata.com/resource/pubmed/keyword/Developing Countries,
http://linkedlifedata.com/resource/pubmed/keyword/Diseases,
http://linkedlifedata.com/resource/pubmed/keyword/French Speaking Africa,
http://linkedlifedata.com/resource/pubmed/keyword/Heterosexuals,
http://linkedlifedata.com/resource/pubmed/keyword/Hiv Infections--transmission,
http://linkedlifedata.com/resource/pubmed/keyword/IMMUNITY,
http://linkedlifedata.com/resource/pubmed/keyword/Incidence,
http://linkedlifedata.com/resource/pubmed/keyword/Measurement,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Prevalence,
http://linkedlifedata.com/resource/pubmed/keyword/Prospective Studies,
http://linkedlifedata.com/resource/pubmed/keyword/Prostitutes--women,
http://linkedlifedata.com/resource/pubmed/keyword/Research Report,
http://linkedlifedata.com/resource/pubmed/keyword/Senegal,
http://linkedlifedata.com/resource/pubmed/keyword/Seroconversion,
http://linkedlifedata.com/resource/pubmed/keyword/Sex Behavior,
http://linkedlifedata.com/resource/pubmed/keyword/Studies,
http://linkedlifedata.com/resource/pubmed/keyword/Viral Diseases,
http://linkedlifedata.com/resource/pubmed/keyword/Western Africa
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0140-6736
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
343
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
943-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7909009-Adult,
pubmed-meshheading:7909009-Cohort Studies,
pubmed-meshheading:7909009-Female,
pubmed-meshheading:7909009-HIV Infections,
pubmed-meshheading:7909009-HIV Seropositivity,
pubmed-meshheading:7909009-HIV-1,
pubmed-meshheading:7909009-HIV-2,
pubmed-meshheading:7909009-Humans,
pubmed-meshheading:7909009-Prospective Studies,
pubmed-meshheading:7909009-Prostitution,
pubmed-meshheading:7909009-Senegal,
pubmed-meshheading:7909009-Time Factors
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pubmed:year |
1994
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pubmed:articleTitle |
Slower heterosexual spread of HIV-2 than HIV-1.
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pubmed:affiliation |
Department of Cancer Biology, Harvard School of Public Health, Boston, MA 02115.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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