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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1994-5-18
|
| pubmed:abstractText |
Four new taxoids were isolated from cell cultures of Taxus baccata. Their structures were elucidated by spectroscopic analyses. Two were the aglycones corresponding to previously isolated 7-O-xylosides of taxol C [1] and 10-deacetyltaxol C [2]. The third [3] had an N-methylated side-chain, while the fourth, named taxcultine [4], contained an n-propyl group on the side-chain. All four compounds actively promoted tubulin assembly. Taxol C [1] showed potent and selective cytotoxicity in the NCI human cell line screen.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0163-3864
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
57
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
116-22
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:7908950-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:7908950-California,
pubmed-meshheading:7908950-Cells, Cultured,
pubmed-meshheading:7908950-Drug Screening Assays, Antitumor,
pubmed-meshheading:7908950-Humans,
pubmed-meshheading:7908950-Magnetic Resonance Spectroscopy,
pubmed-meshheading:7908950-Mass Spectrometry,
pubmed-meshheading:7908950-Molecular Weight,
pubmed-meshheading:7908950-Paclitaxel,
pubmed-meshheading:7908950-Plants, Medicinal,
pubmed-meshheading:7908950-Tubulin
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
New bioactive taxoids from cell cultures of Taxus baccata.
|
| pubmed:affiliation |
PHYTOpharmaceuticals, Inc., San Carlos, California 94070.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|