Linked Life Data

7907658

Source:http://linkedlifedata.com/resource/pubmed/id/7907658

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1994-4-20
pubmed:abstractText
Morphine is the preferred opioid analgesic in pediatric cancer pain due to extensive clinical experience with it, significant pharmacokinetic and pharmacodynamic data following oral and parenteral administration, global availability, and the development of controlled-release formulations. Randomized clinical trials are needed to fully evaluate the pharmacokinetics, dose equivalence, clinical efficacy, and safety of other opioid analgesics in cancer pain. Clinical trials are also needed to evaluate the efficacy and safety of adjuvant analgesics in children, including tricyclic antidepressants, anticonvulsants, and antiarrhythmics for neuropathic pain and corticosteroids and diphosphonates for bone pain. Unfortunately, the number of children with cancer pain and stable analgesic requirements is usually not large enough to support well-controlled clinical trials at a single institution. Consequently, multicentre and perhaps multinational efforts are necessary to fully evaluate opioid pharmacokinetics, pharmacodynamics, and dosage guidelines in children with cancer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0825-8597
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
19-25
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Evaluation and use of opioid analgesics in pediatric cancer pain.
pubmed:publicationType
Journal Article, Review