pubmed-article:7904998 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:7904998 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
pubmed-article:7904998 | lifeskim:mentions | umls-concept:C0022567 | lld:lifeskim |
pubmed-article:7904998 | lifeskim:mentions | umls-concept:C1366557 | lld:lifeskim |
pubmed-article:7904998 | lifeskim:mentions | umls-concept:C1704256 | lld:lifeskim |
pubmed-article:7904998 | lifeskim:mentions | umls-concept:C0221920 | lld:lifeskim |
pubmed-article:7904998 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
pubmed-article:7904998 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
pubmed-article:7904998 | lifeskim:mentions | umls-concept:C0040845 | lld:lifeskim |
pubmed-article:7904998 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
pubmed-article:7904998 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
pubmed-article:7904998 | lifeskim:mentions | umls-concept:C0220905 | lld:lifeskim |
pubmed-article:7904998 | lifeskim:mentions | umls-concept:C0680242 | lld:lifeskim |
pubmed-article:7904998 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:7904998 | pubmed:dateCreated | 1994-2-25 | lld:pubmed |
pubmed-article:7904998 | pubmed:abstractText | Interferon gamma (IFN-gamma) is a potent inducer of squamous differentiation in normal human epidermal keratinocytes. This induction is characterized by a > or = 95% decrease in the mRNA level of two growth regulatory genes, cdc2 and E2F-1, and a 7-15-fold increase in the expression of two squamous cell-specific genes, transglutaminase type I and cornifin. In contrast to the decrease in cdc2 and E2F-1 expression, the increase in transglutaminase type I and cornifin mRNAs by IFN-gamma occurs after a lagtime of more than 12 h. These results are consistent with the hypothesis that in normal human epidermal keratinocyte cells irreversible growth arrest precedes the expression of the squamous-differentiated phenotype. The action of IFN-gamma on the expression of squamous cell-specific genes is antagonized by retinoic acid and transforming growth factor beta 1. Both factors are potent suppressors of the induction of transglutaminase type I and cornifin; however, they do not prevent the commitment to irreversible growth arrest. Several squamous cell carcinoma cell lines do not show a detectable decrease in cdc2 or increase in transglutaminase type I mRNA levels after IFN-gamma treatment and appear to be altered in their control of squamous differentiation. | lld:pubmed |
pubmed-article:7904998 | pubmed:language | eng | lld:pubmed |
pubmed-article:7904998 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7904998 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:7904998 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:7904998 | pubmed:month | Jan | lld:pubmed |
pubmed-article:7904998 | pubmed:issn | 0021-9258 | lld:pubmed |
pubmed-article:7904998 | pubmed:author | pubmed-author:JettenA MAM | lld:pubmed |
pubmed-article:7904998 | pubmed:author | pubmed-author:SaundersN ANA | lld:pubmed |
pubmed-article:7904998 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:7904998 | pubmed:day | 21 | lld:pubmed |
pubmed-article:7904998 | pubmed:volume | 269 | lld:pubmed |
pubmed-article:7904998 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:7904998 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:7904998 | pubmed:pagination | 2016-22 | lld:pubmed |
pubmed-article:7904998 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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pubmed-article:7904998 | pubmed:year | 1994 | lld:pubmed |
pubmed-article:7904998 | pubmed:articleTitle | Control of growth regulatory and differentiation-specific genes in human epidermal keratinocytes by interferon gamma. Antagonism by retinoic acid and transforming growth factor beta 1. | lld:pubmed |
pubmed-article:7904998 | pubmed:affiliation | Cell Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709. | lld:pubmed |
pubmed-article:7904998 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:7904998 | pubmed:publicationType | Comparative Study | lld:pubmed |
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