Linked Life Data

7904998

Source:http://linkedlifedata.com/resource/pubmed/id/7904998

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-2-25
pubmed:abstractText
Interferon gamma (IFN-gamma) is a potent inducer of squamous differentiation in normal human epidermal keratinocytes. This induction is characterized by a > or = 95% decrease in the mRNA level of two growth regulatory genes, cdc2 and E2F-1, and a 7-15-fold increase in the expression of two squamous cell-specific genes, transglutaminase type I and cornifin. In contrast to the decrease in cdc2 and E2F-1 expression, the increase in transglutaminase type I and cornifin mRNAs by IFN-gamma occurs after a lagtime of more than 12 h. These results are consistent with the hypothesis that in normal human epidermal keratinocyte cells irreversible growth arrest precedes the expression of the squamous-differentiated phenotype. The action of IFN-gamma on the expression of squamous cell-specific genes is antagonized by retinoic acid and transforming growth factor beta 1. Both factors are potent suppressors of the induction of transglutaminase type I and cornifin; however, they do not prevent the commitment to irreversible growth arrest. Several squamous cell carcinoma cell lines do not show a detectable decrease in cdc2 or increase in transglutaminase type I mRNA levels after IFN-gamma treatment and appear to be altered in their control of squamous differentiation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
269
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2016-22
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:7904998-CDC2 Protein Kinase, pubmed-meshheading:7904998-Carcinoma, Squamous Cell, pubmed-meshheading:7904998-Cell Differentiation, pubmed-meshheading:7904998-Cell Division, pubmed-meshheading:7904998-Cells, Cultured, pubmed-meshheading:7904998-Cornified Envelope Proline-Rich Proteins, pubmed-meshheading:7904998-DNA Probes, pubmed-meshheading:7904998-Gene Expression Regulation, pubmed-meshheading:7904998-Growth Substances, pubmed-meshheading:7904998-Humans, pubmed-meshheading:7904998-Interferon-gamma, pubmed-meshheading:7904998-Keratinocytes, pubmed-meshheading:7904998-Kinetics, pubmed-meshheading:7904998-Male, pubmed-meshheading:7904998-Membrane Proteins, pubmed-meshheading:7904998-RNA, Messenger, pubmed-meshheading:7904998-Recombinant Proteins, pubmed-meshheading:7904998-Skin, pubmed-meshheading:7904998-Skin Neoplasms, pubmed-meshheading:7904998-Transforming Growth Factor beta, pubmed-meshheading:7904998-Transglutaminases, pubmed-meshheading:7904998-Tretinoin, pubmed-meshheading:7904998-Tumor Cells, Cultured
pubmed:year
1994
pubmed:articleTitle
Control of growth regulatory and differentiation-specific genes in human epidermal keratinocytes by interferon gamma. Antagonism by retinoic acid and transforming growth factor beta 1.
pubmed:affiliation
Cell Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709.
pubmed:publicationType
Journal Article, Comparative Study