Linked Life Data

7900957

Source:http://linkedlifedata.com/resource/pubmed/id/7900957

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-11-26
pubmed:abstractText
1. The roles of the inhibitory neurotransmitter GABA and the excitatory neurotransmitter glutamate in anoxic survival and anoxic death are discussed, with particular reference to the brain. 2. It is pointed out that the metabolic relationship between GABA and glutamate causes the neural levels of GABA to increase and glutamate to decrease during anoxia. 3. It is suggested that increased levels of GABA could mediate metabolic depression, and, thus, anoxic survival in ectothermic as well as endothermic vertebrates. Furthermore, evidence for a role of GABA in hibernation is discussed. 4. A hypothesis is presented suggesting that hypoxia has been a selective pressure in conserving GABA and glutamate as major inhibitory and excitatory neurotransmitters in vertebrates as well as invertebrates.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0742-8413
pubmed:author
pubmed:issnType
Print
pubmed:volume
105
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
329-36
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Role of GABA in hypoxia tolerance, metabolic depression and hibernation--possible links to neurotransmitter evolution.
pubmed:affiliation
Department of Zoophysiology, Uppsala University, Sweden.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Review, Research Support, Non-U.S. Gov't