| pubmed-article:7900855 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7900855 | lifeskim:mentions | umls-concept:C0026844 | lld:lifeskim |
| pubmed-article:7900855 | lifeskim:mentions | umls-concept:C1135918 | lld:lifeskim |
| pubmed-article:7900855 | lifeskim:mentions | umls-concept:C0003009 | lld:lifeskim |
| pubmed-article:7900855 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:7900855 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:7900855 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:7900855 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:7900855 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:7900855 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:7900855 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:7900855 | pubmed:issue | 3 Pt 2 | lld:pubmed |
| pubmed-article:7900855 | pubmed:dateCreated | 1995-4-27 | lld:pubmed |
| pubmed-article:7900855 | pubmed:abstractText | Angiotensin II (ANG II) induces vascular smooth muscle contraction and functions as a growth factor stimulating vascular smooth muscle cell (VSMC) hypertrophy. We wondered whether ANG II might induce expression of alpha 1-adrenergic receptors (ARs) in cultured VSMCs, which would then potentially accentuate the effects of catecholamines in the cells. Rat VSMCs were preincubated with phenoxybenzamine to inactivate alpha 1-ARs; the cells were then treated with ANG II for 24 h. ANG II-treated cells expressed an increased number of alpha 1-ARs compared with controls, suggesting that ANG II increased the rate of alpha 1-AR synthesis. ANG II markedly induced accumulation of alpha 1A/D- and alpha 1B-AR mRNAs in a concentration- and time-dependent manner. This effect of ANG II was blocked by the specific ANG II-receptor agonist [Sar1-Ile8]ANG II. ANG II-induced accumulation of alpha 1A/D-AR mRNAs was completely abolished by transcriptional inhibitor actinomycin D. ANG II markedly increased the transcriptional rate of the alpha 1A/D-AR gene without changing stability of alpha 1A/D-AR mRNAs. Protein kinase C (PKC) activator 4 beta-phorbol 12-myristate 13-acetate also induced accumulation of alpha 1A/D-AR mRNAs, and PKC inhibitor H-7 completely blocked ANG II-induced accumulation of the alpha 1A/D-AR mRNAs. Neither the biologically inactive ANG II analogue des-Phe8-ANG II nor the calcium ionophores A-23187 and BAY K-8466 induced alpha 1A/D-AR mRNAs. Finally, ANG II preincubation increased alpha 1-AR agonist phenylephrine-stimulated expression of the c-fos gene.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
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| pubmed-article:7900855 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7900855 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7900855 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7900855 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7900855 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7900855 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7900855 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7900855 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7900855 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:7900855 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:7900855 | pubmed:author | pubmed-author:OkazakiMM | lld:pubmed |
| pubmed-article:7900855 | pubmed:author | pubmed-author:HoffmanB BBB | lld:pubmed |
| pubmed-article:7900855 | pubmed:author | pubmed-author:SOYY | lld:pubmed |
| pubmed-article:7900855 | pubmed:author | pubmed-author:HuZ WZW | lld:pubmed |
| pubmed-article:7900855 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7900855 | pubmed:volume | 268 | lld:pubmed |
| pubmed-article:7900855 | pubmed:geneSymbol | c-fos | lld:pubmed |
| pubmed-article:7900855 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7900855 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7900855 | pubmed:pagination | H1006-14 | lld:pubmed |
| pubmed-article:7900855 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:7900855 | pubmed:meshHeading | pubmed-meshheading:7900855-... | lld:pubmed |
| pubmed-article:7900855 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7900855 | pubmed:articleTitle | Angiotensin II induces transcription and expression of alpha 1-adrenergic receptors in vascular smooth muscle cells. | lld:pubmed |
| pubmed-article:7900855 | pubmed:affiliation | Department of Medicine, Stanford University School of Medicine, Palo Alto, California. | lld:pubmed |
| pubmed-article:7900855 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7900855 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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