Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0013018,
umls-concept:C0018134,
umls-concept:C0034790,
umls-concept:C0039194,
umls-concept:C0085112,
umls-concept:C0085358,
umls-concept:C0181586,
umls-concept:C0205161,
umls-concept:C0205178,
umls-concept:C0330390,
umls-concept:C0332283,
umls-concept:C0332464,
umls-concept:C0457343,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1704410,
umls-concept:C1706438,
umls-concept:C1882115,
umls-concept:C2698600
|
| pubmed:issue |
4
|
| pubmed:dateCreated |
1995-4-25
|
| pubmed:abstractText |
The persistence and selection of allogeneic CBA/J T lymphocytes were studied during graft-versus-host (GvH) reaction in immunodeficient C.B-17 SCID (SCID) mice. After neonatal injection the donor cells primarily migrated to the spleen plus lymph nodes (SL) and the thymus of the recipients. Thirteen days post engraftment, CD8+ cells in SL had increased five times in cell number with an 18-fold increase of CD8+ V beta 14+ cells, paralleled by clinical signs of GvH disease (GvHD). Donor lymphocytes from these mice were proliferative unresponsive to allogeneic Balb/c or C57Bl/6 SL cells, whereas 8 weeks post injection the tolerance was confined to H-2d specific donor cells. Here, spleens had a total cell content similar to untreated SCID mice but the average percentage of donor cells had reached 25%. Moreover, the CD4/CD8 cell ratio in the donor population in SL and thymus had changed to normal and the TCR V beta repertoire was similar to that of the originally injected cells. Following secondary transfer into syngeneic CBA/Ca nu/nu recipients donor cells regained a significant but reduced response to H-2d stimulators indicating that the antigen specific tolerance of allogeneic donor cells in the SCID mice was due, at least in part, to a reversible state of anergy.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0300-9475
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
41
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
373-83
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:7899825-Acute Disease,
pubmed-meshheading:7899825-Animals,
pubmed-meshheading:7899825-CD4-CD8 Ratio,
pubmed-meshheading:7899825-CD8-Positive T-Lymphocytes,
pubmed-meshheading:7899825-Chronic Disease,
pubmed-meshheading:7899825-Flow Cytometry,
pubmed-meshheading:7899825-Graft vs Host Reaction,
pubmed-meshheading:7899825-Immune Tolerance,
pubmed-meshheading:7899825-Immunophenotyping,
pubmed-meshheading:7899825-Immunotherapy, Adoptive,
pubmed-meshheading:7899825-Lymphocyte Activation,
pubmed-meshheading:7899825-Lymphoid Tissue,
pubmed-meshheading:7899825-Mice,
pubmed-meshheading:7899825-Mice, Inbred BALB C,
pubmed-meshheading:7899825-Mice, Inbred C57BL,
pubmed-meshheading:7899825-Mice, Inbred CBA,
pubmed-meshheading:7899825-Mice, SCID,
pubmed-meshheading:7899825-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:7899825-Severe Combined Immunodeficiency,
pubmed-meshheading:7899825-T-Lymphocytes
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Acute graft-versus-host reaction in SCID mice leads to an abnormal expansion of CD8+ V beta 14+ and a broad inactivation of donor T cells followed by a host-restricted tolerance and a normalization of the TCR V beta repertoire in the chronic phase.
|
| pubmed:affiliation |
National Veterinary Institute, Laboratory for Vaccine Research, Uppsala, Sweden.
|
| pubmed:publicationType |
Journal Article
|