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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1995-4-27
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pubmed:abstractText |
From a structurally distinct set of o-substituted tetraphenylporphyrins, the picket fence porphyrin (PFP), 3,1-meso-tetrakis(o-propionamidophenyl)porphyrin (3,1-TPro) has been selected as a potential candidate for use in the photodynamic therapy (PDT) of cancer. In this report, the time-dependent tissue distribution of 14C-labeled 3,1-TPro is described along with the results of various treatment regimens. The tissue distribution of radiolabeled 3,1-TPro is comparable to that of other porphyrin photosensitizers with the advantage of being most effective at 4 h and being cleared rapidly from most tissues. The results of the various treatment regimen experiments, as well as other studies, indicate that the 3,1-TPro mechanism of action is similar to that of other photosensitizers, but may include some minor differences. The conclusion is that 3,1-TPro and other PFP offer a class of effective photosensitizers that may be exploited for their structural versatility, straightforward synthesis leading to a compound of high purity and known structure, and stability (both in terms of shelf-life and in vivo metabolism) as potential candidates for PDT.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0031-8655
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
90-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7899498-Animals,
pubmed-meshheading:7899498-Cell Division,
pubmed-meshheading:7899498-Female,
pubmed-meshheading:7899498-Mammary Neoplasms, Experimental,
pubmed-meshheading:7899498-Mesoporphyrins,
pubmed-meshheading:7899498-Photochemotherapy,
pubmed-meshheading:7899498-Radiation-Sensitizing Agents,
pubmed-meshheading:7899498-Rats,
pubmed-meshheading:7899498-Rats, Inbred F344,
pubmed-meshheading:7899498-Tissue Distribution
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pubmed:year |
1995
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pubmed:articleTitle |
Photosensitization and tissue distribution studies of the picket fence porphyrin, 3,1-TPro, a candidate for photodynamic therapy.
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pubmed:affiliation |
Department of Chemistry, University of Rochester, College of Arts & Science, NY 14627.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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