Linked Life Data

7891314

Source:http://linkedlifedata.com/resource/pubmed/id/7891314

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1995-4-14
pubmed:abstractText
The functional modulation of norepinephrine (NE) release by serotonergic receptors in the hippocampus of freely moving rats was studied by use of in vivo microdialysis. To stimulate NE release from the nerve terminals, a high concentration of potassium (K+, 120 mM) was added through the perfusion system. The K(+)-evoked NE release was inhibited in a concentration-dependent manner when serotonin (5-HT, 0.01-10 microM) was coperfused with K+. A selective 5-HT3 receptor agonist, 2-methyl-5-HT, mimicked the 5-HT response at a concentration of 0.01 to 10 microM. The 5-HT-induced (1 microM) inhibition of NE release was blocked by pretreatment with ondansetron (1 and 10 microM), a 5-HT3 receptor antagonist. On the other hand, K(+)-evoked NE release was also reduced by coperfusion with the 5-HT reuptake inhibitor, fluoxetine (10 microM), which caused increases in the dialysate 5-HT concentration. The fluoxetine-induced (10 microM) decreases in the K(+)-evoked NE release were prevented by serotonergic denervation caused by pretreatment with 5,7-dihydroxytryptamine (200 micrograms/rat i.c.v.). These results indicate that the inhibition on NE release by fluoxetine was due to increased synaptic concentrations of endogenous 5-HT. The fluoxetine-induced inhibitory effect was furthermore abolished by pretreatment with ondansetron (1 and 10 microM). These findings indicate the possibility that both exogenous and endogenous 5-HT inhibit NE release occurs from the rat hippocampus by 5-HT3 receptors. Thus, the present study suggests that the functional modulation of NE release by 5-HT3 receptors exists in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
272
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1044-51
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Modulation of norepinephrine release by serotonergic receptors in the rat hippocampus as measured by in vivo microdialysis.
pubmed:affiliation
First Department of Pharmacology, Hokkaido University School of Medicine, Sapporo, Japan.
pubmed:publicationType
Journal Article