Linked Life Data

7882004

Source:http://linkedlifedata.com/resource/pubmed/id/7882004

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-4-12
pubmed:abstractText
To investigate the contribution of the hypothalamic cholinergic and noradrenergic neurons in 2-deoxyglucose (2-DG) induced hyperglycemia, we after microwave irradiation analyzed the contents of the neurotransmitters and the metabolites in the microdissected hypothalamic nucleus, ventromedial hypothalamic nucleus (VMH), paraventricular nucleus (PVN) and lateral hypothalamus (LH). A dose dependent decrease in the acetylcholine (ACh) content and a corresponding increase in the choline content was observed in those hypothalamic nuclei 20 min after intravenous administration of 250 or 500 mg/kg 2-DG. The norepinephrine content decreased in 500 mg/kg 2-DG group but did not change significantly in the 250 mg/kg group. These results suggest the involvement and importance of the hypothalamic cholinergic system in 2-DG induced hyperglycemia and, furthermore, that the hyperglycemic response can not be solely attributed to the noradrenergic system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
665
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
13-7
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Hypothalamic cholinergic and noradrenergic neurons in hyperglycemia induced by 2-deoxyglucose.
pubmed:affiliation
Department of Neuropsychopharmacology (Tsumura), Gunma University School of Medicine, Japan.
pubmed:publicationType
Journal Article