Linked Life Data

7877685

Source:http://linkedlifedata.com/resource/pubmed/id/7877685

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6518
pubmed:dateCreated
1995-4-6
pubmed:databankReference
pubmed:abstractText
Heart rate is slowed in part by acetylcholine-dependent activation of a cardiac potassium (K+) channel, IKACh. Activated muscarinic receptors stimulate IKACh via the G-protein beta gamma-subunits. It has been assumed that the inwardly rectifying K(+)-channel gene, GIRK1, alone encodes IKACh. It is now shown that IKACh is a heteromultimer of two distinct inwardly rectifying K(+)-channel subunits, GIRK1 and a newly cloned member of the family, CIR.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
374
pubmed:geneSymbol
GIRK1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
135-41
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:7877685-Amino Acid Sequence, pubmed-meshheading:7877685-Animals, pubmed-meshheading:7877685-Cell Line, pubmed-meshheading:7877685-Cloning, Molecular, pubmed-meshheading:7877685-Dogs, pubmed-meshheading:7877685-G Protein-Coupled Inwardly-Rectifying Potassium Channels, pubmed-meshheading:7877685-GTP-Binding Proteins, pubmed-meshheading:7877685-Ion Channel Gating, pubmed-meshheading:7877685-Membrane Potentials, pubmed-meshheading:7877685-Molecular Sequence Data, pubmed-meshheading:7877685-Myocardium, pubmed-meshheading:7877685-Oocytes, pubmed-meshheading:7877685-Potassium Channels, pubmed-meshheading:7877685-Potassium Channels, Inwardly Rectifying, pubmed-meshheading:7877685-Protein Conformation, pubmed-meshheading:7877685-Rats, pubmed-meshheading:7877685-Recombinant Proteins, pubmed-meshheading:7877685-Xenopus
pubmed:year
1995
pubmed:articleTitle
The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins.
pubmed:affiliation
Department of Pharmacology, Mayo Foundation, Rochester, Minnesota 55905.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't